HIF1AN

Gene Symbol HIF1AN
Entrez Gene 55662
Alt Symbol FIH1
Species Human
Gene Type protein-coding
Description hypoxia inducible factor 1, alpha subunit inhibitor
Other Description FIH-1|factor inhibiting HIF-1|factor inhibiting HIF1|hypoxia-inducible factor 1-alpha inhibitor|hypoxia-inducible factor asparagine hydroxylase|peptide-aspartate beta-dioxygenase
Swissprots Q969Q7 D3DR69 Q9NPV5 Q9NWT6 Q5W147
Accessions CDM55393 CDM55574 EAW49817 EAW49818 Q9NWT6 AF395830 AAL27308 AK000622 BAA91291 AK025680 BAB15213 AK295353 BAG58320 AL359615 CAB94885 AW015561 BC007719 AAH07719 BC015574 DQ892767 ABM83693 DQ896013 ABM87012 XM_011539940 XP_011538242 XM_011539941 XP_011538243 NM_017902 NP_060372
Function Hydroxylates HIF-1 alpha at 'Asp-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300- interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation. {ECO:0000269|PubMed:12042299, ECO:0000269|PubMed:12080085, ECO:0000269|PubMed:17003112, ECO:0000269|PubMed:17573339, ECO:0000269|PubMed:18299578, ECO:0000269|PubMed:19245366, ECO:0000269|PubMed:21177872, ECO:0000269|PubMed:21251231}.
Subcellular Location Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Note=Mainly cytoplasmic localization, but interaction with NOTCH1 results in nuclear localization and interaction with ABPA3 results in perinuclear localization in macrophages.

Human HIF1AN Gene cDNA Clone - orb143547 from Biorbyt

Prices $255.00
Sizes 10 μg
Species Human

Human-HIF1AN-cDNA-Clone - DC02228 from Abgent, a WuXi AppTec company

Prices $471.15
Sizes 10 µg
Species Human
Accession BC007719

HIF1AN - MBS1267004 from MyBioSource

Prices $175.00
Sizes 10ug plasmid + 200ul glycerol stock
Species Human
Accession BC007719

Human HIF1AN ORF Clone(NM_017902.2) - CDCL166025 from Creative Biomart

Species Human
Accession NM_017902.2

Human HIF1AN Gene cDNA clone plasmid - HG14813-G from Sino Biological

Species Human

Human HIF1AN natural ORF mammalian expression plasmid, C-GFPSpark tag - HG14813-ACG from Sino Biological

Species Human
Accession BC007719

Human HIF1AN natural ORF mammalian expression plasmid, C-OFPSpark tag - HG14813-ACR from Sino Biological

Species Human
Accession BC007719

Human HIF1AN natural ORF mammalian expression plasmid, N-OFPSpark tag - HG14813-ANR from Sino Biological

Species Human
Accession BC007719

Human HIF1AN natural ORF mammalian expression plasmid, N-GFPSpark tag - HG14813-ANG from Sino Biological

Species Human
Accession BC007719

Human HIF1AN natural ORF mammalian expression plasmid - HG14813-UT from Sino Biological

Species Human
Accession BC007719

Human HIF1AN natural ORF mammalian expression plasmid, N-Myc tag - HG14813-NM from Sino Biological

Species Human
Accession BC007719

Human HIF1AN ORF Clone (BC007719) - CDCS414554 from Creative biogene

Species Human
Accession Q9NWT6

Human HIF1AN ORF clone (BC007719) - CDCB158759 from Creative biogene

Species Human
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