HIF1AN

Gene Symbol	HIF1AN
Entrez Gene	55662
Alt Symbol	FIH1
Species	Human
Gene Type	protein-coding
Description	hypoxia inducible factor 1, alpha subunit inhibitor
Other Description	FIH-1|factor inhibiting HIF-1|factor inhibiting HIF1|hypoxia-inducible factor 1-alpha inhibitor|hypoxia-inducible factor asparagine hydroxylase|peptide-aspartate beta-dioxygenase
Swissprots	Q969Q7 D3DR69 Q9NPV5 Q9NWT6 Q5W147
Accessions	CDM55393 CDM55574 EAW49817 EAW49818 Q9NWT6 AF395830 AAL27308 AK000622 BAA91291 AK025680 BAB15213 AK295353 BAG58320 AL359615 CAB94885 AW015561 BC007719 AAH07719 BC015574 DQ892767 ABM83693 DQ896013 ABM87012 XM_011539940 XP_011538242 XM_011539941 XP_011538243 NM_017902 NP_060372
Function	Hydroxylates HIF-1 alpha at 'Asp-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300- interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation. {ECO:0000269|PubMed:12042299, ECO:0000269|PubMed:12080085, ECO:0000269|PubMed:17003112, ECO:0000269|PubMed:17573339, ECO:0000269|PubMed:18299578, ECO:0000269|PubMed:19245366, ECO:0000269|PubMed:21177872, ECO:0000269|PubMed:21251231}.
Subcellular Location	Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Note=Mainly cytoplasmic localization, but interaction with NOTCH1 results in nuclear localization and interaction with ABPA3 results in perinuclear localization in macrophages.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

HIF1AN 293T Cell Transient Overexpression Lysate(Denatured) - H00055662-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

HIF1AN overexpression lysate - LY402628 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

HIF1AN 293 Cell Lysate - 402293 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

FIH-1/HIF-1AN Overexpression Lysate (Denatured) - H00055662-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

FIH-1/HIF-1AN Overexpression Lysate (Native) - NBL1-11541 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

FIH-1 (h2): 293T Lysate - sc-159159 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

HIF1AN Over-expression Lysate Product - GWB-9C9A3B from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Panoply™ Human HIF1AN Knockdown Stable Cell Line - CSC-DC006988 from Creative biogene Category Cell Line Species Human

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