HIF1AN

Gene Symbol	HIF1AN
Entrez Gene	55662
Alt Symbol	FIH1
Species	Human
Gene Type	protein-coding
Description	hypoxia inducible factor 1, alpha subunit inhibitor
Other Description	FIH-1|factor inhibiting HIF-1|factor inhibiting HIF1|hypoxia-inducible factor 1-alpha inhibitor|hypoxia-inducible factor asparagine hydroxylase|peptide-aspartate beta-dioxygenase
Swissprots	Q969Q7 D3DR69 Q9NPV5 Q9NWT6 Q5W147
Accessions	CDM55393 CDM55574 EAW49817 EAW49818 Q9NWT6 AF395830 AAL27308 AK000622 BAA91291 AK025680 BAB15213 AK295353 BAG58320 AL359615 CAB94885 AW015561 BC007719 AAH07719 BC015574 DQ892767 ABM83693 DQ896013 ABM87012 XM_011539940 XP_011538242 XM_011539941 XP_011538243 NM_017902 NP_060372
Function	Hydroxylates HIF-1 alpha at 'Asp-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300- interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation. {ECO:0000269|PubMed:12042299, ECO:0000269|PubMed:12080085, ECO:0000269|PubMed:17003112, ECO:0000269|PubMed:17573339, ECO:0000269|PubMed:18299578, ECO:0000269|PubMed:19245366, ECO:0000269|PubMed:21177872, ECO:0000269|PubMed:21251231}.
Subcellular Location	Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Note=Mainly cytoplasmic localization, but interaction with NOTCH1 results in nuclear localization and interaction with ABPA3 results in perinuclear localization in macrophages.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human HIF1AN full length protein - ab86916 from Abcam Category Protein Source E. coli Species Human

Human HIF1AN peptide - ab12306 from Abcam Category Peptide

HIF1AN Antibody Blocking Peptide - LS-E14192 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HIF1AN Antibody Blocking Peptide - LS-E14191 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HIF1AN Antibody Blocking Peptide - LS-E11585 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HIF1AN Antibody Blocking Peptide - LS-E11586 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FIH-1/HIF-1AN Blocking Peptide - NB100-428PEP from Novus Biologicals Category Peptide Prices $69.00 Sizes 50 µg Species Human

Recombinant Human FIH-1/HIF-1AN Protein - H00055662-P01 from Novus Biologicals Category Protein Prices $529.00 Sizes 25 µg Source Wheat Germ Species Human

Recombinant Human FIH-1/HIF-1AN Protein - NBC1-22596 from Novus Biologicals Category Protein Prices $249.00 Sizes 100 µg Source E.coli Species Human

HIF1AN Protein (OPPA02059) - OPPA02059 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 10 µg Source E. Coli

Human HIF1 alpha Inhibitor protein - orb81159 from Biorbyt Category Protein Prices $230.00, $442.00 Sizes 10 μg, 50 μg Source E.coli Species Human

HIF1AN protein - 30R-1240 from Fitzgerald Category Protein Prices $180.00 Sizes 100 µg Source E.coli

HIF1AN / FIH1 (1-349) - AR09113PU-L from Acris Antibodies Category Protein Prices $585.00 Sizes 500 µg Source E. coli Species Human

HIF1AN / FIH1 (1-349) - AR09113PU-N from Acris Antibodies Category Protein Prices $270.00 Sizes 100 µg Source E. coli Species Human

HIF1AN / FIH1 - H00055662-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

HIF1AN / FIH1 - H00055662-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Hypoxia-Inducible Factor-1 Alpha Inhibitor, Human Recombinant - 228-10708-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Source Escherichia Coli. Species Human

Recombinant Human HIF1AN - 228-10708-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source Escherichia Coli. Species Human

Recombinant Human HIF1AN - 228-10708-3 from RayBiotech Category Protein Prices $1,950.00 Sizes 3 µg Source Escherichia Coli. Species Human

HIF1AN, 1-349aa, Human, Recombinant, E.coli - 01-2009 from ARP American Research Products Category Protein Prices $139.00, $299.00, $639.00 Sizes 20 µg, 100 µg, 500 µg Source E.coli Species Human

HIF1AN fusion protein - Ag0997 from Proteintech Group Category Protein Source E. coli -derived, PGEX-4T Species Human

HIF1AN Human - PRPS-669 from NeoScientific Category Protein Prices $65.00, $169.00, $2,340.00 Sizes 10 µg, 50 µg, 1 mg Source Escherichia Coli. Species Human

Recombinant Human Hypoxia-Inducible Factor-1 Alpha Inhibitor Protein - BP002318-PRO-662 from Syd Labs Category Protein Prices $160.00, $1,800.00 Sizes 50 µg, 1 mg Source E. coli-derived. Species Human

HIF1AN, 1-349aa, Recombinant Protein - GWB-P0171B from Genway Biotech Category Protein Prices $210.00, $630.00 Sizes 100 μg, 500 μg Source E.coli Species Human

Recombinant Human Hypoxia-Inducible Factor 1, Alpha Subunit Inhibitor - HIF1AN-361H from Creative Biomart Category Protein Source Escherichia Coli.

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