MDK

Gene Symbol MDK
Entrez Gene 4192
Alt Symbol ARAP, MK, NEGF2
Species Human
Gene Type protein-coding
Description midkine (neurite growth-promoting factor 2)
Other Description amphiregulin-associated protein|midgestation and kidney protein|midkine|neurite outgrowth-promoting factor 2|retinoic acid inducible factor
Swissprots Q2LEK4 P21741 Q9UCC7
Accessions AAA59850 BAA01457 CCD35255 EAW68005 P21741 AI494596 AK130889 AK308210 AK309963 BC011704 AAH11704 BF684205 BI915189 BM016739 BM761575 BM887813 BX346163 CN266354 CN266369 CN266376 DQ323888 ABC55425 DQ323889 ABC55426 DQ323890 ABC55427 DQ893220 ABM84146 DQ896549 ABM87548 M69148 AAA58478 X55110 CAA38908 XM_011520116 XP_011518418 NM_001012333 NP_001012333 NM_001012334 NP_001012334 NM_001270550 NP_001257479 NM_001270551 NP_001257480 NM_001270552 NP_001257481 NM_002391 NP_002382 NR_073039
Function Developmentally regulated, secreted growth factor homologous to pleiotrophin (PTN), which has heparin binding activity. Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation. Involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. Also involved in early fetal adrenal gland development (By similarity). {ECO:0000250}.
Subcellular Location Secreted.
Tissue Specificity Expressed in various tumor cell lines. In insulinoma tissue predominantly expressed in precancerous lesions. {ECO:0000269|PubMed:17379400}.

MK (A-9) - sc-46701 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MK (A-9): sc-46701. Western blot analysis of human recombinant MK.

MK (C-18) - sc-1396 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
MK (C-18): sc-1396. Western blot analysis of human recombinant MK.

MK (H-65) - sc-20715 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
MK (H-65): sc-20715. Western blot analysis of human recombinant MK.

MK (M-18) - sc-1398 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
MK (M-18): sc-1398. Western blot analysis of human recombinant MK.

MK (N-17) - sc-1397 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
MK (N-17): sc-1397. Western blot analysis of human recombinant MK.

Anti-Midkine antibody - ab53508 from Abcam

Host Duck
Clonality Polyclonal

Anti-Midkine antibody - ab110614 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-Midkine antibody - ab137793 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Midkine antibody (ab137793) at 1/200 dilutionLane 1 : HeLa S3 whole cell lysateLane 2 : Hep G2 whole cell lysateLysates/proteins at 30 µg per lane.

Anti-Midkine antibody (Biotin) - ab83160 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-Midkine antibody [EP1143Y] - ab52637 from Abcam

Prices $391.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP1143Y
Anti-Midkine antibody [EP1143Y] (ab52637) at 1/500 dilution + Recombinant protein at 0.001 µgSecondaryGoat anti-rabbit HRP labeled at 1/2000 dilution

Anti-Midkine antibody [SC4] - ab52320 from Abcam

Host Mouse
Clonality Monoclonal
Clone SC4

Anti-Midkine antibody - C-terminal - ab170820 from Abcam

Prices $384.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-Midkine antibody - C-terminal (ab170820) at 1/100 dilution + Mouse kidney tissue lysate at 35 µg

Anti-Midkine antibody - N-terminal - ab80234 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab80234 at 1/10 dilution, staining Midkine in human testis by Immunohistochemistry using formalin-fixed, paraffin-embedded tissue, followed by a peroxidase-conjugated secondary antibody and DAB staining.

Anti-MDK / Midkine Antibody - LS-C48891 from LifeSpan Bioscience

Prices $410.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MDK / Midkine Antibody (Biotin) - LS-C104571 from LifeSpan Bioscience

Prices $285.00, $325.00
Sizes 25 µg, 50 µg
Host Rabbit
Clonality Polyclonal

Anti-MDK / Midkine Antibody - LS-C124131 from LifeSpan Bioscience

Prices $465.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-MDK / Midkine Antibody (C-Terminus) - LS-C146247 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
MDK / Midkine antibody LS-C146247 Western blot of 3 Cell lysate. Antibody concentration 1 ug/ml.

Anti-MDK / Midkine Antibody - LS-C155447 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Sample (30 ug of whole cell lysate) A: MCF-7 15% SDS PAGE MDK / Midkine antibody diluted at 1:1000

Anti-MDK / Midkine Antibody - LS-C285700 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MDK / Midkine Antibody (Asp143) - LS-C177625 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of MK (D143) pAb in extracts from 293 cells.

Anti-MDK / Midkine Antibody (aa22-140) - LS-C295374 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MDK / Midkine Antibody (aa22-143, Biotin) - LS-C297528 from LifeSpan Bioscience

Prices $405.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal

Anti-MDK / Midkine Antibody IHC-plus™ - LS-B8221 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-Midkine antibody IHC of human small intestine, goblet cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B8221 dilution 5 ug/ml.

Anti-MDK / Midkine Antibody (aa94-143) - LS-C199924 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of MK antibody in extracts from 293 cells.

Anti-MDK / Midkine Antibody - LS-C192260 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of MDK pAb in extracts from SW480 cells.
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