MDK
| Gene Symbol | MDK |
|---|---|
| Entrez Gene | 4192 |
| Alt Symbol | ARAP, MK, NEGF2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | midkine (neurite growth-promoting factor 2) |
| Other Description | amphiregulin-associated protein|midgestation and kidney protein|midkine|neurite outgrowth-promoting factor 2|retinoic acid inducible factor |
| Swissprots | Q2LEK4 P21741 Q9UCC7 |
| Accessions | AAA59850 BAA01457 CCD35255 EAW68005 P21741 AI494596 AK130889 AK308210 AK309963 BC011704 AAH11704 BF684205 BI915189 BM016739 BM761575 BM887813 BX346163 CN266354 CN266369 CN266376 DQ323888 ABC55425 DQ323889 ABC55426 DQ323890 ABC55427 DQ893220 ABM84146 DQ896549 ABM87548 M69148 AAA58478 X55110 CAA38908 XM_011520116 XP_011518418 NM_001012333 NP_001012333 NM_001012334 NP_001012334 NM_001270550 NP_001257479 NM_001270551 NP_001257480 NM_001270552 NP_001257481 NM_002391 NP_002382 NR_073039 |
| Function | Developmentally regulated, secreted growth factor homologous to pleiotrophin (PTN), which has heparin binding activity. Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation. Involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. Also involved in early fetal adrenal gland development (By similarity). {ECO:0000250}. |
| Subcellular Location | Secreted. |
| Tissue Specificity | Expressed in various tumor cell lines. In insulinoma tissue predominantly expressed in precancerous lesions. {ECO:0000269|PubMed:17379400}. |
MK CRISPR/Cas9 KO Plasmid (h) - sc-402064 from Santa Cruz Biotechnology
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MK HDR Plasmid (h) - sc-402064-HDR from Santa Cruz Biotechnology
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MK Double Nickase Plasmid (h) - sc-402064-NIC from Santa Cruz Biotechnology
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MK Double Nickase Plasmid (h2) - sc-402064-NIC-2 from Santa Cruz Biotechnology
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MK CRISPR Activation Plasmid (h) - sc-402064-ACT from Santa Cruz Biotechnology
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MK CRISPR Activation Plasmid (h2) - sc-402064-ACT-2 from Santa Cruz Biotechnology
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MK Lentiviral Activation Particles (h) - sc-402064-LAC from Santa Cruz Biotechnology
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MK Lentiviral Activation Particles (h2) - sc-402064-LAC-2 from Santa Cruz Biotechnology
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MK siRNA (h) - sc-39711 from Santa Cruz Biotechnology
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MK shRNA Plasmid (h) - sc-39711-SH from Santa Cruz Biotechnology
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MK shRNA (h) Lentiviral Particles - sc-39711-V from Santa Cruz Biotechnology
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Midkine RNAi - H00004192-R01 from Novus Biologicals
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MISSION® esiRNA - EHU151371 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN13143 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13143 from Sigma-Aldrich
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MDK siRNA (Human) - CRH2852 from Cohesion Biosciences
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Midkine RNAi - H00004192-R02 from Novus Biologicals
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Midkine RNAi - H00004192-R03 from Novus Biologicals
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shRNA set against Human MDK (NM_002391.4) - SHH339651 from Creative biogene
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MDK shRNA Plasmid (Human) - CHH2852 from Cohesion Biosciences
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MDK miRNA 3'UTR clone - MiUTR3H-01522 from Creative biogene
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MDK miRNA 3'UTR clone - MiUTR3H-01523 from Creative biogene
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MDK miRNA 3'UTR clone - MiUTR3H-01524 from Creative biogene
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