MDK

Gene Symbol	MDK
Entrez Gene	4192
Alt Symbol	ARAP, MK, NEGF2
Species	Human
Gene Type	protein-coding
Description	midkine (neurite growth-promoting factor 2)
Other Description	amphiregulin-associated protein|midgestation and kidney protein|midkine|neurite outgrowth-promoting factor 2|retinoic acid inducible factor
Swissprots	Q2LEK4 P21741 Q9UCC7
Accessions	AAA59850 BAA01457 CCD35255 EAW68005 P21741 AI494596 AK130889 AK308210 AK309963 BC011704 AAH11704 BF684205 BI915189 BM016739 BM761575 BM887813 BX346163 CN266354 CN266369 CN266376 DQ323888 ABC55425 DQ323889 ABC55426 DQ323890 ABC55427 DQ893220 ABM84146 DQ896549 ABM87548 M69148 AAA58478 X55110 CAA38908 XM_011520116 XP_011518418 NM_001012333 NP_001012333 NM_001012334 NP_001012334 NM_001270550 NP_001257479 NM_001270551 NP_001257480 NM_001270552 NP_001257481 NM_002391 NP_002382 NR_073039
Function	Developmentally regulated, secreted growth factor homologous to pleiotrophin (PTN), which has heparin binding activity. Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation. Involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. Also involved in early fetal adrenal gland development (By similarity). {ECO:0000250}.
Subcellular Location	Secreted.
Tissue Specificity	Expressed in various tumor cell lines. In insulinoma tissue predominantly expressed in precancerous lesions. {ECO:0000269|PubMed:17379400}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

MDK-Over-expression-Lysate - LY10072a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

MDK 293T Cell Transient Overexpression Lysate(Denatured) - H00004192-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

MDK 293T Cell Transient Overexpression Lysate(Denatured) - H00004192-T02 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

MDK overexpression lysate - LY419358 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

MDK overexpression lysate - LY423327 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

MDK overexpression lysate - LY423328 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

MDK overexpression lysate - LY425316 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

MDK 293 Cell Lysate - 409909 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

Midkine Overexpression Lysate (Denatured) - H00004192-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Midkine Overexpression Lysate (Denatured) - H00004192-T02 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl Species Human

Midkine Overexpression Lysate (Native) - NBL1-12968 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

MK (h): 293T Lysate - sc-159960 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

MDK Over-expression Lysate Product - GWB-6CCCF5 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Human Midkine / MDK Insect Cell Lysate (WB positive control) - 10247-HNABL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human Midkine Baculovirus-Insect Cells Transfected Lysate (positive control) (denatured) - orb175056 from Biorbyt Category Cell Lysate Prices $425.00 Sizes 300 μg Species Human

Midkine Overexpression Lysate (Native) - NBP2-10999 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Midkine Overexpression Lysate (Native) - NBP2-11177 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Panoply™ Human MDK Knockdown Stable Cell Line - CSC-DC009339 from Creative biogene Category Cell Line Species Human

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