MDK

Gene Symbol	MDK
Entrez Gene	4192
Alt Symbol	ARAP, MK, NEGF2
Species	Human
Gene Type	protein-coding
Description	midkine (neurite growth-promoting factor 2)
Other Description	amphiregulin-associated protein|midgestation and kidney protein|midkine|neurite outgrowth-promoting factor 2|retinoic acid inducible factor
Swissprots	Q2LEK4 P21741 Q9UCC7
Accessions	AAA59850 BAA01457 CCD35255 EAW68005 P21741 AI494596 AK130889 AK308210 AK309963 BC011704 AAH11704 BF684205 BI915189 BM016739 BM761575 BM887813 BX346163 CN266354 CN266369 CN266376 DQ323888 ABC55425 DQ323889 ABC55426 DQ323890 ABC55427 DQ893220 ABM84146 DQ896549 ABM87548 M69148 AAA58478 X55110 CAA38908 XM_011520116 XP_011518418 NM_001012333 NP_001012333 NM_001012334 NP_001012334 NM_001270550 NP_001257479 NM_001270551 NP_001257480 NM_001270552 NP_001257481 NM_002391 NP_002382 NR_073039
Function	Developmentally regulated, secreted growth factor homologous to pleiotrophin (PTN), which has heparin binding activity. Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation. Involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. Also involved in early fetal adrenal gland development (By similarity). {ECO:0000250}.
Subcellular Location	Secreted.
Tissue Specificity	Expressed in various tumor cell lines. In insulinoma tissue predominantly expressed in precancerous lesions. {ECO:0000269|PubMed:17379400}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active mouse Midkine full length protein - ab123474 from Abcam Category Protein Prices $110.00, $239.00 Sizes 5 µg, 20 µg Source E. coli Species Mouse

Human Midkine full length protein - ab49848 from Abcam Category Protein Source E. coli Species Human

Human Midkine full length protein - ab73234 from Abcam Category Protein Source E. coli Species Human

Human Midkine full length protein - ab78470 from Abcam Category Protein Source E. coli Species Human

Mouse Midkine peptide - ab36571 from Abcam Category Peptide

MDK / Midkine Antibody Blocking Peptide - LS-E1410 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MDK / Midkine Antibody Blocking Peptide - LS-E23131 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Midkine Protein - NBP2-34997 from Novus Biologicals Category Protein Prices $69.00, $169.00, $2,669.00 Sizes 5 µg, 20 µg, 1 mg Source E. coli Species Human

Midkine Recombinant Protein - H00004192-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Species Human

Recombinant Human Midkine Protein - NBP1-30185 from Novus Biologicals Category Protein Prices $299.00 Sizes 100 µg Source E.coli Species Human

Midkine Recombinant Protein - P4078 from Novus Biologicals Category Protein Prices $549.00 Sizes 20 µg Species Human

Recombinant Human Midkine Protein - NBP1-99245 from Novus Biologicals Category Protein Prices $180.00 Sizes 20 µg Source E. coli Species Human

Midkine Protein - NBP1-99712 from Novus Biologicals Category Protein Species Human

MDK-Antibody-C-term-Blocking-peptide - BP12076b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Midkine recombinant protein - GTX65169 from GeneTex Category Protein Prices $249.00 Sizes 20 μg Source E. coli Species Human

Midkine Recombinant Protein (Active) - GTX48400-PRO from GeneTex Category Protein Prices $299.00 Sizes 20 μg Source E. coli Species Human

Recombinant Human Midkine, CF - 258-MD-010 from R&D Systems Category Protein Source E. coli-derived, Lys23-Asp143

Recombinant Human Midkine, CF - 258-MD-050 from R&D Systems Category Protein Source E. coli-derived, Lys23-Asp143

Recombinant human Midkine (OPCA00875) - OPCA00875 from Aviva Systems Biology Category Protein Prices $220.00 Sizes 50 µg Species Human

Midkine Protein (OPPA00703) - OPPA00703 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

Human Midkine protein - orb78541 from Biorbyt Category Protein Prices $255.00, $391.00, $519.00 Sizes 10 μg, 50 μg, 100 μg Species Human

Human Midkine protein - orb80524 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source E.coli

Rat Midkine protein - orb168823 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source E. coli

Human Midkine protein - orb176087 from Biorbyt Category Protein Prices $349.00, $434.00 Sizes 5 μl, 20 μl

Human MDK protein - orb245465 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

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