MDK

Gene Symbol	MDK
Entrez Gene	4192
Alt Symbol	ARAP, MK, NEGF2
Species	Human
Gene Type	protein-coding
Description	midkine (neurite growth-promoting factor 2)
Other Description	amphiregulin-associated protein|midgestation and kidney protein|midkine|neurite outgrowth-promoting factor 2|retinoic acid inducible factor
Swissprots	Q2LEK4 P21741 Q9UCC7
Accessions	AAA59850 BAA01457 CCD35255 EAW68005 P21741 AI494596 AK130889 AK308210 AK309963 BC011704 AAH11704 BF684205 BI915189 BM016739 BM761575 BM887813 BX346163 CN266354 CN266369 CN266376 DQ323888 ABC55425 DQ323889 ABC55426 DQ323890 ABC55427 DQ893220 ABM84146 DQ896549 ABM87548 M69148 AAA58478 X55110 CAA38908 XM_011520116 XP_011518418 NM_001012333 NP_001012333 NM_001012334 NP_001012334 NM_001270550 NP_001257479 NM_001270551 NP_001257480 NM_001270552 NP_001257481 NM_002391 NP_002382 NR_073039
Function	Developmentally regulated, secreted growth factor homologous to pleiotrophin (PTN), which has heparin binding activity. Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation. Involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. Also involved in early fetal adrenal gland development (By similarity). {ECO:0000250}.
Subcellular Location	Secreted.
Tissue Specificity	Expressed in various tumor cell lines. In insulinoma tissue predominantly expressed in precancerous lesions. {ECO:0000269|PubMed:17379400}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human MDK gene - orb90839 from Biorbyt Prices $255.00 Sizes 10 μg Species Human

Human-MDK-cDNA-Clone - DC03165 from Abgent, a WuXi AppTec company Prices $193.05 Sizes 10 µg Species Human Accession NM_002391

MDK - MBS1277154 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC011704

Human MDK ORF Clone(NM_002391.4) - CDCL169837 from Creative Biomart Species Human Accession NM_002391.4

Human Midkine transcript variant 2 Gene ORF cDNA clone in cloning vector - HG10247-M from Sino Biological Species Human

Human Midkine transcript variant 2 Gene ORF cDNA clone expression plasmid, N-His tag - HG10247-NH from Sino Biological Species Human

Human Midkine transcript variant 2 Gene ORF cDNA clone expression plasmid - HG10247-UT from Sino Biological Species Human

Human Midkine transcript variant 2 Gene ORF cDNA clone expression plasmid, C-HA tag - HG10247-CY from Sino Biological Species Human

Human Midkine transcript variant 2 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG10247-NF from Sino Biological Species Human

Human Midkine transcript variant 2 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10247-CF from Sino Biological Species Human

Human Midkine transcript variant 2 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG10247-NM from Sino Biological Species Human

Human Midkine transcript variant 2 Gene ORF cDNA clone expression plasmid, C-His tag - HG10247-CH from Sino Biological Species Human

Human Midkine transcript variant 2 Gene ORF cDNA clone expression plasmid, N-HA tag - HG10247-NY from Sino Biological Species Human

Human Midkine transcript variant 2 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG10247-CM from Sino Biological Species Human

Human MDK / NEGF2 transcript variant 2 Gene cDNA Clone (full-length ORF Clone), expression ready, FLAG-tagged - HG10247-M-F from Sino Biological Species Human Accession NM_001012333.1

Human Midkine transcript variant 2 Gene ORF cDNA clone expression plasmid, C-His tag - HG10247-M-H from Sino Biological Species Human

Human Midkine transcript variant 2 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG10247-ACR from Sino Biological Species Human

Human Midkine transcript variant 2 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG10247-ACG from Sino Biological Species Human

Human MDK ORF Clone (BC011704) - CDCS406487 from Creative biogene Species Human Accession P21741

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