Gene Symbol | MZB1 |
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Entrez Gene | 51237 |
Alt Symbol | MEDA-7, PACAP, pERp1 |
Species | Human |
Gene Type | protein-coding |
Description | marginal zone B and B1 cell-specific protein |
Other Description | HSPC190|caspase-2 binding protein|marginal zone B- and B1-cell-specific protein|mesenteric estrogen-dependent adipose 7|mesenteric oestrogen-dependent adipose gene- 7|plasma cell-induced ER protein 1|plasma cell-induced resident ER protein|plasma cell-induced resident endoplasmic reticulum protein|proapoptotic caspase adapter protein|proapoptotic caspase adaptor protein |
Swissprots | Q9P0T3 Q96RL5 Q7Z6N2 Q8WU39 D2IYS0 |
Accessions | Q8WU39 AA837360 AF151024 AAF36110 AF338109 AAK84085 AK057549 BAG51934 AK292706 BAF85395 BC009931 AAH09931 BC021275 AAH21275 BU601458 DQ892627 ABM83553 EU176703 ABW03504 GQ477350 ACY74343 NM_016459 NP_057543 |
Function | Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity (By similarity). Isoform 2 may be involved in regulation of apoptosis. Helps to diversify peripheral B-cell functions by regulating Ca(2+) stores, antibody secretion and integrin activation. {ECO:0000250}. |
Subcellular Location | Isoform 1: Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138}. Secreted. |
Tissue Specificity | Widely expressed with highest levels in adult brain, small intestine and lymphoid tissues such as thymus and spleen. Expression is frequently lower in intestinal-type gastric cancer. In obese patients, more abundant in omental than in subcutaneous fat. {ECO:0000269|PubMed:11350957, ECO:0000269|PubMed:12792799, ECO:0000269|PubMed:19805157}. |
Human PACAP ELISA Kit - abx054871 from Abbexa
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Adenylate Cyclase Activating Polypeptide 1, Pituitary (ADCYAP1), Human, ELISA Kit - SEB347Hu from ARP American Research Products
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Pituitary Adenylate Cyclase Activating Polypeptide, PACAP, Mouse, ELISA Kit - E-EL-M0910 from ARP American Research Products
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Human PACAP ELISA Kit - HP0592 from NeoScientific
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Anserine PACAP ELISA Kit - AP0592 from NeoScientific
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proapoptotic caspase adaptor protein (PACAP) , ELISA Kit - MBS9310970 from MyBioSource
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Human Pituitary adenylate cyclase activating polypeptide ELISA - E01P0585 from BlueGene Biotech
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ELISA Kit for Adenylate Cyclase Activating Polypeptide 1, Pituitary (ADCYAP1) - CEB347Hu from Cloud-clone
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Adenylate Cyclase Activating Polypeptide 1, Pituitary (ADCYAP1), Human, ELISA Kit - DL-ADCYAP1-Hu from ARP American Research Products
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Human PACAP ELISA Kit - E029430 from Biobool
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Human MZB1 ELISA Kit - E090704 from Biobool
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Human PACAP ELISA Kit - EHP0592 from ABclonal
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Human Plasma cell-induced resident endoplasmic reticulum protein,pERp1 ELISA Kit - EK3757 from Signalway Antibody
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anti-PACAP antibody - ARG65036 from Arigo Biolaboratories
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MZB1 ELISA Kit (Human) (OKEH06532) - OKEH06532 from Aviva Systems Biology
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Plasma cell-induced resident endoplasmic reticulum protein, pERp1, ELISA Kit - MBS9427587 from MyBioSource
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