| Gene Symbol | MZB1 |
|---|---|
| Entrez Gene | 51237 |
| Alt Symbol | MEDA-7, PACAP, pERp1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | marginal zone B and B1 cell-specific protein |
| Other Description | HSPC190|caspase-2 binding protein|marginal zone B- and B1-cell-specific protein|mesenteric estrogen-dependent adipose 7|mesenteric oestrogen-dependent adipose gene- 7|plasma cell-induced ER protein 1|plasma cell-induced resident ER protein|plasma cell-induced resident endoplasmic reticulum protein|proapoptotic caspase adapter protein|proapoptotic caspase adaptor protein |
| Swissprots | Q9P0T3 Q96RL5 Q7Z6N2 Q8WU39 D2IYS0 |
| Accessions | Q8WU39 AA837360 AF151024 AAF36110 AF338109 AAK84085 AK057549 BAG51934 AK292706 BAF85395 BC009931 AAH09931 BC021275 AAH21275 BU601458 DQ892627 ABM83553 EU176703 ABW03504 GQ477350 ACY74343 NM_016459 NP_057543 |
| Function | Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity (By similarity). Isoform 2 may be involved in regulation of apoptosis. Helps to diversify peripheral B-cell functions by regulating Ca(2+) stores, antibody secretion and integrin activation. {ECO:0000250}. |
| Subcellular Location | Isoform 1: Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138}. Secreted. |
| Tissue Specificity | Widely expressed with highest levels in adult brain, small intestine and lymphoid tissues such as thymus and spleen. Expression is frequently lower in intestinal-type gastric cancer. In obese patients, more abundant in omental than in subcutaneous fat. {ECO:0000269|PubMed:11350957, ECO:0000269|PubMed:12792799, ECO:0000269|PubMed:19805157}. |
MGC29506 CRISPR/Cas9 KO Plasmid (h) - sc-406694 from Santa Cruz Biotechnology
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MGC29506 HDR Plasmid (h) - sc-406694-HDR from Santa Cruz Biotechnology
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MGC29506 Double Nickase Plasmid (h) - sc-406694-NIC from Santa Cruz Biotechnology
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MGC29506 Double Nickase Plasmid (h2) - sc-406694-NIC-2 from Santa Cruz Biotechnology
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MGC29506 CRISPR Activation Plasmid (h) - sc-406694-ACT from Santa Cruz Biotechnology
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MGC29506 CRISPR Activation Plasmid (h2) - sc-406694-ACT-2 from Santa Cruz Biotechnology
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MGC29506 Lentiviral Activation Particles (h) - sc-406694-LAC from Santa Cruz Biotechnology
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MGC29506 Lentiviral Activation Particles (h2) - sc-406694-LAC-2 from Santa Cruz Biotechnology
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MGC29506 siRNA (h) - sc-91924 from Santa Cruz Biotechnology
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MGC29506 shRNA Plasmid (h) - sc-91924-SH from Santa Cruz Biotechnology
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MGC29506 shRNA (h) Lentiviral Particles - sc-91924-V from Santa Cruz Biotechnology
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MGC29506 siRNA (h) - sc-106218 from Santa Cruz Biotechnology
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MGC29506 shRNA Plasmid (h) - sc-106218-SH from Santa Cruz Biotechnology
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MGC29506 shRNA (h) Lentiviral Particles - sc-106218-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU098211 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN14891 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14891 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00735 from Sigma-Aldrich
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MZB1 siRNA (Human) - CRH9626 from Cohesion Biosciences
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Proapoptotic Caspase Adaptor Protein RNAi - H00051237-R01 from Novus Biologicals
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MGC29506 CRISPR/Cas9 KO Plasmid (h2) - sc-406694-KO-2 from Santa Cruz Biotechnology
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MGC29506 HDR Plasmid (h2) - sc-406694-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human Mzb1 (NM_016459.3) - SHH348600 from Creative biogene
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shRNA set against Human MGC29506(NM_016459.3) - SHH188183 from Creative biogene
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Human MZB1 siRNA - orb270128 from Biorbyt
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