| Gene Symbol |
MZB1
|
| Entrez Gene |
51237
|
| Alt Symbol |
MEDA-7, PACAP, pERp1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
marginal zone B and B1 cell-specific protein
|
| Other Description |
HSPC190|caspase-2 binding protein|marginal zone B- and B1-cell-specific protein|mesenteric estrogen-dependent adipose 7|mesenteric oestrogen-dependent adipose gene- 7|plasma cell-induced ER protein 1|plasma cell-induced resident ER protein|plasma cell-induced resident endoplasmic reticulum protein|proapoptotic caspase adapter protein|proapoptotic caspase adaptor protein
|
| Swissprots |
Q9P0T3 Q96RL5 Q7Z6N2 Q8WU39 D2IYS0
|
| Accessions |
Q8WU39 AA837360 AF151024 AAF36110 AF338109 AAK84085 AK057549 BAG51934 AK292706 BAF85395 BC009931 AAH09931 BC021275 AAH21275 BU601458 DQ892627 ABM83553 EU176703 ABW03504 GQ477350 ACY74343 NM_016459 NP_057543
|
| Function |
Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity (By similarity). Isoform 2 may be involved in regulation of apoptosis. Helps to diversify peripheral B-cell functions by regulating Ca(2+) stores, antibody secretion and integrin activation. {ECO:0000250}.
|
| Subcellular Location |
Isoform 1: Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138}. Secreted.
|
| Tissue Specificity |
Widely expressed with highest levels in adult brain, small intestine and lymphoid tissues such as thymus and spleen. Expression is frequently lower in intestinal-type gastric cancer. In obese patients, more abundant in omental than in subcutaneous fat. {ECO:0000269|PubMed:11350957, ECO:0000269|PubMed:12792799, ECO:0000269|PubMed:19805157}.
|