SIGIRR

Gene Symbol SIGIRR
Entrez Gene 59307
Alt Symbol TIR8
Species Human
Gene Type protein-coding
Description single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
Other Description single Ig IL-1-related receptor|single Ig IL-1R-related molecule|single immunoglobulin domain IL1R1 related|single immunoglobulin domain-containing IL1R-related protein|toll/interleukin-1 receptor 8
Swissprots Q6UXI3 Q9H733 Q6IA17 Q3KQY2
Accessions CAH68705 EAX02324 Q6IA17 AK025099 BAB15066 AK093427 AK172830 BAD18795 AY358342 AAQ88708 BC003591 AAH03591 BC025953 AAH25953 BC106007 AAI06008 BX369506 CR457338 CAG33619 DA963481 DB112269 DQ893453 ABM84379 DQ896290 ABM87289 XM_005253044 XP_005253101 XM_005253045 XP_005253102 XM_005253046 XP_005253103 XM_005253048 XP_005253105 XM_011520254 XP_011518556 XR_930884 XR_930885 NM_001135053 NP_001128525 NM_001135054 NP_001128526 NM_021805 NP_068577
Function Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP. {ECO:0000269|PubMed:12925853, ECO:0000269|PubMed:14715412, ECO:0000269|PubMed:15866876}.
Subcellular Location Membrane {ECO:0000305}; Single-pass type III membrane protein {ECO:0000305}.
Tissue Specificity Mainly expressed in epithelial tissues such as kidney, lung and gut. {ECO:0000269|PubMed:14715412, ECO:0000269|PubMed:21077278}.

SIGIRR (A-4) - sc-271864 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SIGIRR (A-4): sc-271864. Western blot analysis of SIGIRR expression in non-transfected: sc-117752 (A) and human SIGIRR transfected: sc-111731 (B) 293T whole cell lysates.

SIGIRR (D-2) - sc-365601 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SIGIRR (D-2): sc-365601. Western blot analysis of SIGIRR expression in A549 whole cell lysate.

SIGIRR (H-186) - sc-98976 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
SIGIRR (H-186): sc-98976. Western blot analysis of SIGIRR expression in HeLa whole cell lysate.

SIGIRR (N-13) - sc-47408 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SIGIRR (N-13): sc-47408. Western blot analysis of SIGIRR expression in non-transfected: sc-117752 (A) and human SIGIRR transfected: sc-111731 (B) 293T whole cell lysates.

SIGIRR (C-12) - sc-47405 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SIGIRR (C-12): sc-47405. Western blot analysis of SIGIRR expression in MDCK (A), Ramos (B), A549 (C) and Caki-1 (D) whole cell lysates.

SIGIRR (C-18) - sc-47406 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SIGIRR (C-18): sc-47406. Western blot analysis of SIGIRR expression in non-transfected: sc-117752 (A) and human SIGIRR transfected: sc-111731 (B) 293T whole cell lysates.

Anti-SIGIRR antibody - ab25875 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SIGIRR antibody - ab81516 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-SIGIRR antibody - ab22053 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-SIGIRR antibody (ab22053) at 0.5 µg/mlLane 1 : human kidney cell lysateLane 2 : mouse kidney cell lysateLysates/proteins at 15 µg per lane.Observed band size : 45,50 kDa (why is the actual band size different from the predicted?)

Anti-SIGIRR antibody [EPR12638] - ab177937 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR12638
Anti-SIGIRR antibody [EPR12638] (ab177937) at 1/1000 dilution + Fetal kidney lysate at 10 µg

Anti-SIGIRR antibody [MM0547-10D5] - ab90253 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone MM0547-10D5

Anti-SIGIRR Antibody (aa309-323) - LS-C10155 from LifeSpan Bioscience

Prices $435.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SIGIRR Antibody (APC) - LS-C132109 from LifeSpan Bioscience

Prices $590.00
Sizes 100 tst
Host Mouse
Clonality Monoclonal

Anti-SIGIRR Antibody (C-Terminus) - LS-C124546 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SIGIRR Antibody (aa1-118) - LS-C296437 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SIGIRR Antibody (aa1-117, Biotin) - LS-C297188 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SIGIRR Antibody (aa1-118, Biotin) - LS-C299652 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SIGIRR Antibody (aa1-118, FITC) - LS-C301982 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SIGIRR Antibody (aa1-118, Biotin) - LS-C299653 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SIGIRR Antibody (aa1-118, FITC) - LS-C301983 from LifeSpan Bioscience

Prices $530.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SIGIRR Antibody (aa1-117, FITC) - LS-C304044 from LifeSpan Bioscience

Prices $495.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SIGIRR Antibody (aa309-323) - LS-C798 from LifeSpan Bioscience

Prices $335.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Western blot of SIGIRR in40 ugs of A) HCT-116 and B) A549cell lysate using antibody at 1:500 dilution.

Anti-SIGIRR Antibody (aa1-117) - LS-C296440 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant SIGIRR.

Anti-SIGIRR Antibody (aa1-118) - LS-C296439 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant SIGIRR.

Anti-SIGIRR Antibody (aa334-358) - LS-C816 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of human TIR8 in 15 ugs of (A) human kidney and (B) mouse kidney cell lysate using antibody at 0.5 ug/ml.
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