SIGIRR

Gene Symbol	SIGIRR
Entrez Gene	59307
Alt Symbol	TIR8
Species	Human
Gene Type	protein-coding
Description	single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
Other Description	single Ig IL-1-related receptor|single Ig IL-1R-related molecule|single immunoglobulin domain IL1R1 related|single immunoglobulin domain-containing IL1R-related protein|toll/interleukin-1 receptor 8
Swissprots	Q6UXI3 Q9H733 Q6IA17 Q3KQY2
Accessions	CAH68705 EAX02324 Q6IA17 AK025099 BAB15066 AK093427 AK172830 BAD18795 AY358342 AAQ88708 BC003591 AAH03591 BC025953 AAH25953 BC106007 AAI06008 BX369506 CR457338 CAG33619 DA963481 DB112269 DQ893453 ABM84379 DQ896290 ABM87289 XM_005253044 XP_005253101 XM_005253045 XP_005253102 XM_005253046 XP_005253103 XM_005253048 XP_005253105 XM_011520254 XP_011518556 XR_930884 XR_930885 NM_001135053 NP_001128525 NM_001135054 NP_001128526 NM_021805 NP_068577
Function	Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP. {ECO:0000269|PubMed:12925853, ECO:0000269|PubMed:14715412, ECO:0000269|PubMed:15866876}.
Subcellular Location	Membrane {ECO:0000305}; Single-pass type III membrane protein {ECO:0000305}.
Tissue Specificity	Mainly expressed in epithelial tissues such as kidney, lung and gut. {ECO:0000269|PubMed:14715412, ECO:0000269|PubMed:21077278}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SIGIRR-Over-expression-Lysate - LY13350a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

SIGIRR 293T Cell Transient Overexpression Lysate(Denatured) - H00059307-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

SIGIRR overexpression lysate - LY402876 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

SIGIRR overexpression lysate - LY427540 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

SIGIRR overexpression lysate - LY427541 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

SIGIRR 293 Cell Lysate - 402502 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

SIGIRR Overexpression Lysate (Denatured) - H00059307-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

SIGIRR Overexpression Lysate (Native) - NBL1-15956 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

SIGIRR (h): 293T Lysate - sc-111731 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

SIGIRR Over-expression Lysate Product - GWB-3FDE07 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Human SIGIRR / TIR8 HEK293 Cell Lysate (WB positive control) - 12165-H08HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human SIGIRR / TIR8 HEK293 Cell Lysate (WB positive control) - 12165-H02HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human SIGIRR Human Cells Transfected Lysate (positive control) (denatured) - orb173699 from Biorbyt Category Cell Lysate Prices $425.00 Sizes 300 μg Species Human

Human SIGIRR Human Cells Transfected Lysate (positive control) (denatured) - orb174578 from Biorbyt Category Cell Lysate Prices $425.00 Sizes 300 μg Species Human

SIGIRR Overexpression Lysate (Native) - NBP2-09563 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

SIGIRR Overexpression Lysate (Native) - NBP2-09562 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

SIGIRR Overexpression Lysate (Denatured) - H00059307-T02 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

Panoply™ Human SIGIRR Knockdown Stable Cell Line - CSC-DC014236 from Creative biogene Category Cell Line Species Human

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