SIGIRR

Gene Symbol	SIGIRR
Entrez Gene	59307
Alt Symbol	TIR8
Species	Human
Gene Type	protein-coding
Description	single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
Other Description	single Ig IL-1-related receptor|single Ig IL-1R-related molecule|single immunoglobulin domain IL1R1 related|single immunoglobulin domain-containing IL1R-related protein|toll/interleukin-1 receptor 8
Swissprots	Q6UXI3 Q9H733 Q6IA17 Q3KQY2
Accessions	CAH68705 EAX02324 Q6IA17 AK025099 BAB15066 AK093427 AK172830 BAD18795 AY358342 AAQ88708 BC003591 AAH03591 BC025953 AAH25953 BC106007 AAI06008 BX369506 CR457338 CAG33619 DA963481 DB112269 DQ893453 ABM84379 DQ896290 ABM87289 XM_005253044 XP_005253101 XM_005253045 XP_005253102 XM_005253046 XP_005253103 XM_005253048 XP_005253105 XM_011520254 XP_011518556 XR_930884 XR_930885 NM_001135053 NP_001128525 NM_001135054 NP_001128526 NM_021805 NP_068577
Function	Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP. {ECO:0000269|PubMed:12925853, ECO:0000269|PubMed:14715412, ECO:0000269|PubMed:15866876}.
Subcellular Location	Membrane {ECO:0000305}; Single-pass type III membrane protein {ECO:0000305}.
Tissue Specificity	Mainly expressed in epithelial tissues such as kidney, lung and gut. {ECO:0000269|PubMed:14715412, ECO:0000269|PubMed:21077278}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human-SIGIRR-cDNA-Clone - DC01342 from Abgent, a WuXi AppTec company Prices $553.50 Sizes 10 µg Species Human Accession BC003591

SIGIRR - MBS1267250 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC003591

Human SIGIRR cDNA clone(NM_001135053.1) - CDFH017553 from Creative Biomart Species Human Accession NM_001135053.1

Human SIGIRR cDNA clone(NM_001135054.1) - CDFH017554 from Creative Biomart Species Human Accession NM_001135054.1

Human SIGIRR ORF Clone(NM_021805.2) - CDCL175466 from Creative Biomart Species Human Accession NM_021805.2

Human SIGIRR ORF Clone(NM_001135053.1) - CDCR350202 from Creative Biomart Species Human Accession NM_001135053.1

Human SIGIRR ORF Clone(NM_001135053.1) - CDCR350203 from Creative Biomart Species Human Accession NM_001135053.1

Human SIGIRR ORF Clone(NM_001135054.1) - CDCR350204 from Creative Biomart Species Human Accession NM_001135054.1

Human SIGIRR ORF Clone(NM_001135054.1) - CDCR350205 from Creative Biomart Species Human Accession NM_001135054.1

human SIGIRR ORF clone - CDCH080164 from Creative Biomart Species Human Accession NM_001135053

human SIGIRR ORF clone - CDCH080165 from Creative Biomart Species Human Accession NM_001135053

human SIGIRR ORF clone - CDCH080166 from Creative Biomart Species Human Accession NM_001135053

human SIGIRR ORF clone - CDCH080167 from Creative Biomart Species Human Accession NM_001135053

Human SIGIRR/TIR8 Gene ORF cDNA clone in cloning vector - HG12165-G from Sino Biological Species Human

Human SIGIRR/TIR8 Gene ORF cDNA clone expression plasmid - HG12165-UT from Sino Biological Species Human

Human SIGIRR/TIR8 Gene ORF cDNA clone expression plasmid, N-HA tag - HG12165-NY from Sino Biological Species Human

Human SIGIRR/TIR8 Gene ORF cDNA clone expression plasmid, N-His tag - HG12165-NH from Sino Biological Species Human

Human SIGIRR/TIR8 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG12165-ACR from Sino Biological Species Human

Human SIGIRR/TIR8 Gene ORF cDNA clone expression plasmid, C-His tag - HG12165-CH from Sino Biological Species Human

Human SIGIRR/TIR8 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG12165-NF from Sino Biological Species Human

Human SIGIRR/TIR8 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG12165-ACG from Sino Biological Species Human

Human SIGIRR/TIR8 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG12165-NM from Sino Biological Species Human

Human SIGIRR/TIR8 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG12165-CF from Sino Biological Species Human

Human SIGIRR/TIR8 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG12165-CM from Sino Biological Species Human

Human SIGIRR/TIR8 Gene ORF cDNA clone expression plasmid, C-HA tag - HG12165-CY from Sino Biological Species Human

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