SIGIRR
| Gene Symbol | SIGIRR |
|---|---|
| Entrez Gene | 59307 |
| Alt Symbol | TIR8 |
| Species | Human |
| Gene Type | protein-coding |
| Description | single immunoglobulin and toll-interleukin 1 receptor (TIR) domain |
| Other Description | single Ig IL-1-related receptor|single Ig IL-1R-related molecule|single immunoglobulin domain IL1R1 related|single immunoglobulin domain-containing IL1R-related protein|toll/interleukin-1 receptor 8 |
| Swissprots | Q6UXI3 Q9H733 Q6IA17 Q3KQY2 |
| Accessions | CAH68705 EAX02324 Q6IA17 AK025099 BAB15066 AK093427 AK172830 BAD18795 AY358342 AAQ88708 BC003591 AAH03591 BC025953 AAH25953 BC106007 AAI06008 BX369506 CR457338 CAG33619 DA963481 DB112269 DQ893453 ABM84379 DQ896290 ABM87289 XM_005253044 XP_005253101 XM_005253045 XP_005253102 XM_005253046 XP_005253103 XM_005253048 XP_005253105 XM_011520254 XP_011518556 XR_930884 XR_930885 NM_001135053 NP_001128525 NM_001135054 NP_001128526 NM_021805 NP_068577 |
| Function | Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP. {ECO:0000269|PubMed:12925853, ECO:0000269|PubMed:14715412, ECO:0000269|PubMed:15866876}. |
| Subcellular Location | Membrane {ECO:0000305}; Single-pass type III membrane protein {ECO:0000305}. |
| Tissue Specificity | Mainly expressed in epithelial tissues such as kidney, lung and gut. {ECO:0000269|PubMed:14715412, ECO:0000269|PubMed:21077278}. |
Human SIGIRR full length protein - ab132120 from Abcam
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Human SIGIRR peptide - ab75025 from Abcam
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Human SIGIRR protein fragment - ab108572 from Abcam
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Mouse SIGIRR peptide - ab39849 from Abcam
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SIGIRR Antibody Blocking Peptide - LS-E17927 from LifeSpan Bioscience
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Recombinant Human SIGIRR Protein - H00059307-P01 from Novus Biologicals
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Recombinant Human SIGIRR Fc Chimera, CF - 990-SG-100 from R&D Systems
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Human SIGIRR His tag protein - orb84184 from Biorbyt
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Human SIGIRR protein - orb139655 from Biorbyt
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SIGIRR Blocking Peptide - 33R-7406 from Fitzgerald
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Human SIGIRR Protein - abx069096 from Abbexa
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SIGIRR / TIR8 - H00059307-P01-10 from Acris Antibodies
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SIGIRR / TIR8 - H00059307-P01-25 from Acris Antibodies
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SIGIRR / TIR8 Control Peptide - AP30779CP-N from Acris Antibodies
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Single Ig IL1 Related Receptor (SIGIRR), Human - 20-9519 from ARP American Research Products
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SIGIRR Peptide - 3367P from ProSci
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Recombinant Human SIGIRR, His tagged - SIGIRR-3956H from Creative Biomart
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Recombinant Human SIGIRR, Fc-tagged - SIGIRR-28784TH from Creative Biomart
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Recombinant Human SIGIRR, His-tagged - SIGIRR-28785TH from Creative Biomart
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Recombinant Human SIGIRR - SIGIRR-1681H from Creative Biomart
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Recombinant Human SIGIRR, Fc Chimera - SIGIRR-2422H from Creative Biomart
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Recombinant Human SIGIRR, Fc tagged - SIGIRR-422H from Creative Biomart
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Recombinant Single Ig IL1 Related Receptor (SIGIRR) - RPM229Hu01 from Uscn Life Science Inc.
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Recombinant Single Ig IL1 Related Receptor (SIGIRR) - RPM229Mu01 from Uscn Life Science Inc.
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Recombinant Single Ig IL1 Related Receptor (SIGIRR) - RPM229Ra01 from Uscn Life Science Inc.
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