SIGIRR

Gene Symbol SIGIRR
Entrez Gene 59307
Alt Symbol TIR8
Species Human
Gene Type protein-coding
Description single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
Other Description single Ig IL-1-related receptor|single Ig IL-1R-related molecule|single immunoglobulin domain IL1R1 related|single immunoglobulin domain-containing IL1R-related protein|toll/interleukin-1 receptor 8
Swissprots Q6UXI3 Q9H733 Q6IA17 Q3KQY2
Accessions CAH68705 EAX02324 Q6IA17 AK025099 BAB15066 AK093427 AK172830 BAD18795 AY358342 AAQ88708 BC003591 AAH03591 BC025953 AAH25953 BC106007 AAI06008 BX369506 CR457338 CAG33619 DA963481 DB112269 DQ893453 ABM84379 DQ896290 ABM87289 XM_005253044 XP_005253101 XM_005253045 XP_005253102 XM_005253046 XP_005253103 XM_005253048 XP_005253105 XM_011520254 XP_011518556 XR_930884 XR_930885 NM_001135053 NP_001128525 NM_001135054 NP_001128526 NM_021805 NP_068577
Function Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP. {ECO:0000269|PubMed:12925853, ECO:0000269|PubMed:14715412, ECO:0000269|PubMed:15866876}.
Subcellular Location Membrane {ECO:0000305}; Single-pass type III membrane protein {ECO:0000305}.
Tissue Specificity Mainly expressed in epithelial tissues such as kidney, lung and gut. {ECO:0000269|PubMed:14715412, ECO:0000269|PubMed:21077278}.

SIGIRR CRISPR/Cas9 KO Plasmid (h) - sc-404074 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SIGIRR HDR Plasmid (h) - sc-404074-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SIGIRR Double Nickase Plasmid (h) - sc-404074-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SIGIRR Double Nickase Plasmid (h2) - sc-404074-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SIGIRR CRISPR Activation Plasmid (h) - sc-404074-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SIGIRR CRISPR Activation Plasmid (h2) - sc-404074-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SIGIRR Lentiviral Activation Particles (h) - sc-404074-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SIGIRR Lentiviral Activation Particles (h2) - sc-404074-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SIGIRR siRNA (h) - sc-61547 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SIGIRR shRNA Plasmid (h) - sc-61547-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SIGIRR shRNA (h) Lentiviral Particles - sc-61547-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SIGIRR RNAi - H00059307-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU035171 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN19325 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19325 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR01064 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr01064

SIGIRR siRNA (Human) - CRJ1768 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SIGIRR - MBS8210661 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human SIGIRR (NM_021805.2) - SHH407408 from Creative biogene

Category siRNA
Species Reactivities Human

Human SIGIRR siRNA - orb272269 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SIGIRR shRNA Plasmid (Human) - CHJ1768 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SIGIRR miRNA 3'UTR clone - MiUTR3H-07716 from Creative biogene

Species Reactivities Human

SIGIRR miRNA 3'UTR clone - MiUTR3H-07717 from Creative biogene

Species Reactivities Human

SIGIRR miRNA 3'UTR clone - MiUTR3H-07718 from Creative biogene

Species Reactivities Human
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