SIGIRR

Gene Symbol	SIGIRR
Entrez Gene	59307
Alt Symbol	TIR8
Species	Human
Gene Type	protein-coding
Description	single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
Other Description	single Ig IL-1-related receptor|single Ig IL-1R-related molecule|single immunoglobulin domain IL1R1 related|single immunoglobulin domain-containing IL1R-related protein|toll/interleukin-1 receptor 8
Swissprots	Q6UXI3 Q9H733 Q6IA17 Q3KQY2
Accessions	CAH68705 EAX02324 Q6IA17 AK025099 BAB15066 AK093427 AK172830 BAD18795 AY358342 AAQ88708 BC003591 AAH03591 BC025953 AAH25953 BC106007 AAI06008 BX369506 CR457338 CAG33619 DA963481 DB112269 DQ893453 ABM84379 DQ896290 ABM87289 XM_005253044 XP_005253101 XM_005253045 XP_005253102 XM_005253046 XP_005253103 XM_005253048 XP_005253105 XM_011520254 XP_011518556 XR_930884 XR_930885 NM_001135053 NP_001128525 NM_001135054 NP_001128526 NM_021805 NP_068577
Function	Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP. {ECO:0000269|PubMed:12925853, ECO:0000269|PubMed:14715412, ECO:0000269|PubMed:15866876}.
Subcellular Location	Membrane {ECO:0000305}; Single-pass type III membrane protein {ECO:0000305}.
Tissue Specificity	Mainly expressed in epithelial tissues such as kidney, lung and gut. {ECO:0000269|PubMed:14715412, ECO:0000269|PubMed:21077278}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SIGIRR / Single Ig IL-1-related Receptor ELISA Kit - RAB0735 from Sigma-Aldrich Category ELISA Kit Prices $637.00 Sizes 1 kt

SIGIRR (Human) IP-WB Antibody Pair - H00059307-PW1 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

Custom Human SIGIRR ELISA - ELH-SIGIRR from RayBiotech Category ELISA Kit Prices $615.00, $1,107.00, $2,460.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

single immunoglobulin and toll-interleukin 1 receptor (TIR) domain, ELISA Kit - MBS9318786 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 5.0 pg/ml. Range 31.2 pg/ml - 1000 pg/ml.

Custom Human SIGIRR ELISA Kit - orb158984 from Biorbyt Category ELISA Kit Prices $1,148.00, $1,981.00, $4,284.00 Sizes 96 well, 192 assays, 480 assays

Human SIGIRR ELISA - ELH-SIGIRR-1 from RayBiotech Category ELISA Kit Prices $615.00, $1,107.00, $2,460.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

Human SIGIRR ELISA Kit - E035328 from Biobool Category ELISA Kit Sensitivity 5.0 pg/ml.

Single Ig IL-1-Related Receptor (SIGIRR), ELISA Kit - MBS9364644 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Single Ig IL-1-Related Receptor (SIGIRR), ELISA Kit - MBS9366449 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Single Ig IL-1-Related Receptor (SIGIRR), ELISA Kit - MBS9347343 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Single Ig IL-1-Related Receptor (SIGIRR), ELISA Kit - MBS9365885 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Single Ig IL-1-Related Receptor (SIGIRR), ELISA Kit - MBS9364188 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Single Ig IL-1-Related Receptor (SIGIRR), ELISA Kit - MBS9345659 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Single Ig IL-1-Related Receptor (SIGIRR), ELISA Kit - MBS9347310 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Single Ig IL-1-Related Receptor (SIGIRR), ELISA Kit - MBS9352104 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Single Ig IL-1-Related Receptor (SIGIRR), ELISA Kit - MBS9354024 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Single Ig IL-1-Related Receptor (SIGIRR), ELISA Kit - MBS9343990 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Single Ig IL-1-Related Receptor (SIGIRR), ELISA Kit - MBS9360842 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Single Ig IL-1-Related Receptor (SIGIRR), ELISA Kit - MBS9362439 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Single Ig IL-1-Related Receptor (SIGIRR), ELISA Kit - MBS9360195 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Single Ig IL-1-Related Receptor (SIGIRR), ELISA Kit - MBS9367057 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Single Ig IL-1-Related Receptor (SIGIRR), ELISA Kit - MBS9344510 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Single Ig IL-1-Related Receptor (SIGIRR), ELISA Kit - MBS9364508 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Single Ig IL-1-Related Receptor (SIGIRR), ELISA Kit - MBS9370666 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Single Ig IL-1-Related Receptor (SIGIRR), ELISA Kit - MBS9360321 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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