| Gene Symbol |
LRP5
|
| Entrez Gene |
4041
|
| Alt Symbol |
BMND1, EVR1, EVR4, HBM, LR3, LRP-5, LRP7, OPPG, OPS, OPTA1, VBCH2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
low density lipoprotein receptor-related protein 5
|
| Other Description |
low density lipoprotein receptor-related protein 7|low-density lipoprotein receptor-related protein 5
|
| Swissprots |
Q9UES7 Q9UP66 Q96TD6 O75197
|
| Accessions |
AAK52433 EAW74705 EAW74706 O75197 AA279383 AA953315 AB017498 BAA33051 AF064548 AAC36467 AF077820 AAC72791 AF088027 AI583742 BC098397 BC150595 AAI50596 DN999254 XM_005273994 XP_005274051 XM_011545029 XP_011543331 XM_011545030 XP_011543332 XM_011545031 XP_011543333 XR_949925 XR_949926 NM_001291902 NP_001278831 NM_002335 NP_002326
|
| Function |
Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor- ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3- mediated phosphorylation and destruction of beta-catenin. Appears be required for postnatal control of vascular regression in the eye. Required for posterior patterning of the epiblast during gastrulation. {ECO:0000269|PubMed:11336703, ECO:0000269|PubMed:11448771, ECO:0000269|PubMed:14727154, ECO:0000269|PubMed:14731402, ECO:0000269|PubMed:15778503}.
|
| Subcellular Location |
Membrane; Single-pass type I membrane protein. Endoplasmic reticulum {ECO:0000250}. Note=Chaperoned to the plasma membrane by MESD. {ECO:0000250}.
|
| Tissue Specificity |
Widely expressed, with the highest level of expression in the liver and in aorta. {ECO:0000269|PubMed:9790987}.
|
| Top Pathways |
Wnt signaling pathway
|