LRP5

Gene Symbol LRP5
Entrez Gene 4041
Alt Symbol BMND1, EVR1, EVR4, HBM, LR3, LRP-5, LRP7, OPPG, OPS, OPTA1, VBCH2
Species Human
Gene Type protein-coding
Description low density lipoprotein receptor-related protein 5
Other Description low density lipoprotein receptor-related protein 7|low-density lipoprotein receptor-related protein 5
Swissprots Q9UES7 Q9UP66 Q96TD6 O75197
Accessions AAK52433 EAW74705 EAW74706 O75197 AA279383 AA953315 AB017498 BAA33051 AF064548 AAC36467 AF077820 AAC72791 AF088027 AI583742 BC098397 BC150595 AAI50596 DN999254 XM_005273994 XP_005274051 XM_011545029 XP_011543331 XM_011545030 XP_011543332 XM_011545031 XP_011543333 XR_949925 XR_949926 NM_001291902 NP_001278831 NM_002335 NP_002326
Function Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor- ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3- mediated phosphorylation and destruction of beta-catenin. Appears be required for postnatal control of vascular regression in the eye. Required for posterior patterning of the epiblast during gastrulation. {ECO:0000269|PubMed:11336703, ECO:0000269|PubMed:11448771, ECO:0000269|PubMed:14727154, ECO:0000269|PubMed:14731402, ECO:0000269|PubMed:15778503}.
Subcellular Location Membrane; Single-pass type I membrane protein. Endoplasmic reticulum {ECO:0000250}. Note=Chaperoned to the plasma membrane by MESD. {ECO:0000250}.
Tissue Specificity Widely expressed, with the highest level of expression in the liver and in aorta. {ECO:0000269|PubMed:9790987}.
Top Pathways Wnt signaling pathway

LRP5 (D80F2) Rabbit mAb - 5731 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D80F2
Western blot analysis of extracts from HeLa, HCT 116, and SW620 cells using LRP5 (D80F2) Rabbit mAb.

LRP5 (D23F7) Rabbit mAb - 3889 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D23F7
Western blot analysis of extracts from various cell lines using LRP5 (D23F7) Rabbit mAb.

LRP5 (D5G4) Rabbit mAb - 5440 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D5G4
Western blot analysis of extracts from HeLa and SW620 cells using LRP5 (D5G4) Rabbit mAb.

LRP5 (B-9) - sc-390267 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
LRP5 (B-9): sc-390267. Western blot analysis of LRP5 expression in non-transfected: sc-117752 (A) and mouse LRP5 transfected: sc-121400 (B) 293T whole cell lysates.

LRP5 (C-20) - sc-21390 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
LRP5 (C-20): sc-21390. Western blot analysis of LRP5 expression in non-transfected: sc-117752 (A) and mouse LRP5 transfected: sc-121400 (B) 293T whole cell lysates.

LRP5 (H-105) - sc-134463 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
LRP5 (H-105): sc-134463. Western blot analysis of LRP5 expression in non-transfected: sc-117752 (A) and mouse LRP5 transfected: sc-121400 (B) 293T whole cell lysates.

LRP5 (Y-20) - sc-21389 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
LRP5 (Y-20): sc-21389. Western blot analysis of LRP5 expression in non-transfected: sc-117752 (A) and mouse LRP5 transfected: sc-121400 (B) 293T whole cell lysates.

Anti-LRP5 (phospho T1492) antibody - ab203306 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded human lung carcinoma tissue labeling LRP5 with ab203306 at 1/200 dilution followed by conjugation to the secondary antibody and DAB staining.

Anti-LRP5 antibody - ab36121 from Abcam

Prices $385.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
ab36121 at 1ug/ml staining LRP5 in human pancreas tissue section by Immunohistochemistry (Formalin/PFA fixed paraffin-embedded sections). Tissue underwent antigen retrieval in microwave and in Tris/EDTA buffer (pH 9). HRP-staining procedure was used for detection.

Anti-LRP5 antibody - ab38311 from Abcam

Prices $385.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-LRP5 antibody (ab38311) at 1/1000 dilutionLane 1 : recombinant human LRP5 transfected 293 cell lysatesLane 2 : mouse LRP5 transfected 293 cell lysatesLysates/proteins at 35 µg per lane.SecondaryPeroxidase-conjugated goat anti-rabbit IgG (H+L) at 1/5000 dilution

Anti-LRP5 antibody - ab203201 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin/PFA-fixed paraffin-embedded mouse colon carcinoma tissue  labeling LRP5 with ab203201 at a 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.

Anti-LRP5 antibody - ab101845 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-LRP5 antibody (ab101845) at 1 µg/ml + Liver (Human) Tissue Lysate - adult normal tissue (ab29889) at 10 µgSecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-LRP5 antibody - ab55450 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab55450 LRP5 antibody at 1ug/ml.

Anti-LRP5 antibody [2B11] - ab129357 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2B11
ab129357, at 1/200 dilution (green) and negative control (red) staining LRP5 in HeLa cells by flow cytometry.

Anti-LRP5 antibody [31E7] - ab129118 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 31E7
All lanes : Anti-LRP5 antibody [31E7] (ab129118)Lane 1 : HEK293 (Human embryonic kidney cell line) Whole Cell LysateLane 2 : 293T Overexpressing Human LRP5 - Whole Cell LysateLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Mouse IgG H&L (HRP) preadsorbed (ab97040) at 1/10000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-LRP5 antibody - C-terminal - ab187756 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-LRP5 antibody - C-terminal - ab175005 from Abcam

Host Rabbit
Clonality Polyclonal
Anti-LRP5 antibody - C-terminal (ab175005) at 1/1000 dilution + Jurkat total cell extract

Anti-LRP5 Antibody (aa1553-1568) - LS-C3084 from LifeSpan Bioscience

Prices $285.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-LRP5 Antibody (C-Terminus) - LS-C8514 from LifeSpan Bioscience

Prices $345.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-LRP5 Antibody (C-Terminus) - LS-C155139 from LifeSpan Bioscience

Prices $245.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-LRP5 Antibody (aa1178-1189) - LS-C47561 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-LRP5 Antibody (aa1422-1615) - LS-C184843 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Sheep
Clonality Polyclonal

Anti-LRP5 Antibody (C-Terminus, clone D80F2) - LS-C183950 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone D80F2

Anti-LRP5 Antibody (aa1163-1190, AP) - LS-C262133 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LRP5 Antibody (aa1163-1190, APC) - LS-C262134 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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