LRP5

Gene Symbol LRP5
Entrez Gene 4041
Alt Symbol BMND1, EVR1, EVR4, HBM, LR3, LRP-5, LRP7, OPPG, OPS, OPTA1, VBCH2
Species Human
Gene Type protein-coding
Description low density lipoprotein receptor-related protein 5
Other Description low density lipoprotein receptor-related protein 7|low-density lipoprotein receptor-related protein 5
Swissprots Q9UES7 Q9UP66 Q96TD6 O75197
Accessions AAK52433 EAW74705 EAW74706 O75197 AA279383 AA953315 AB017498 BAA33051 AF064548 AAC36467 AF077820 AAC72791 AF088027 AI583742 BC098397 BC150595 AAI50596 DN999254 XM_005273994 XP_005274051 XM_011545029 XP_011543331 XM_011545030 XP_011543332 XM_011545031 XP_011543333 XR_949925 XR_949926 NM_001291902 NP_001278831 NM_002335 NP_002326
Function Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor- ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3- mediated phosphorylation and destruction of beta-catenin. Appears be required for postnatal control of vascular regression in the eye. Required for posterior patterning of the epiblast during gastrulation. {ECO:0000269|PubMed:11336703, ECO:0000269|PubMed:11448771, ECO:0000269|PubMed:14727154, ECO:0000269|PubMed:14731402, ECO:0000269|PubMed:15778503}.
Subcellular Location Membrane; Single-pass type I membrane protein. Endoplasmic reticulum {ECO:0000250}. Note=Chaperoned to the plasma membrane by MESD. {ECO:0000250}.
Tissue Specificity Widely expressed, with the highest level of expression in the liver and in aorta. {ECO:0000269|PubMed:9790987}.
Top Pathways Wnt signaling pathway

LRP5 CRISPR/Cas9 KO Plasmid (h) - sc-401331 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

LRP5 HDR Plasmid (h) - sc-401331-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LRP5 Double Nickase Plasmid (h) - sc-401331-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LRP5 Double Nickase Plasmid (h2) - sc-401331-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LRP5 CRISPR Activation Plasmid (h) - sc-401331-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

LRP5 CRISPR Activation Plasmid (h2) - sc-401331-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

LRP5 Lentiviral Activation Particles (h) - sc-401331-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LRP5 Lentiviral Activation Particles (h2) - sc-401331-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LRP5 siRNA (h) - sc-43900 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

LRP5 shRNA Plasmid (h) - sc-43900-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

LRP5 shRNA (h) Lentiviral Particles - sc-43900-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

LRP-5 RNAi - H00004041-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN12696 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND12696 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR01318 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr01318

LRP5 siRNA (Human) - CRH2732 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human LRP5 (NM_002335.2) - SHH334055 from Creative biogene

Category siRNA
Species Reactivities Human

Human LRP5 siRNA - orb263234 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

LRP5 shRNA Plasmid (Human) - CHH2732 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

LRP5 miRNA 3'UTR clone - MiUTR1H-05900 from Creative biogene

Species Reactivities Human
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