LRP5

Gene Symbol LRP5
Entrez Gene 4041
Alt Symbol BMND1, EVR1, EVR4, HBM, LR3, LRP-5, LRP7, OPPG, OPS, OPTA1, VBCH2
Species Human
Gene Type protein-coding
Description low density lipoprotein receptor-related protein 5
Other Description low density lipoprotein receptor-related protein 7|low-density lipoprotein receptor-related protein 5
Swissprots Q9UES7 Q9UP66 Q96TD6 O75197
Accessions AAK52433 EAW74705 EAW74706 O75197 AA279383 AA953315 AB017498 BAA33051 AF064548 AAC36467 AF077820 AAC72791 AF088027 AI583742 BC098397 BC150595 AAI50596 DN999254 XM_005273994 XP_005274051 XM_011545029 XP_011543331 XM_011545030 XP_011543332 XM_011545031 XP_011543333 XR_949925 XR_949926 NM_001291902 NP_001278831 NM_002335 NP_002326
Function Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor- ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3- mediated phosphorylation and destruction of beta-catenin. Appears be required for postnatal control of vascular regression in the eye. Required for posterior patterning of the epiblast during gastrulation. {ECO:0000269|PubMed:11336703, ECO:0000269|PubMed:11448771, ECO:0000269|PubMed:14727154, ECO:0000269|PubMed:14731402, ECO:0000269|PubMed:15778503}.
Subcellular Location Membrane; Single-pass type I membrane protein. Endoplasmic reticulum {ECO:0000250}. Note=Chaperoned to the plasma membrane by MESD. {ECO:0000250}.
Tissue Specificity Widely expressed, with the highest level of expression in the liver and in aorta. {ECO:0000269|PubMed:9790987}.
Top Pathways Wnt signaling pathway

Mouse LRP-5 (NP_032539) VersaClone cDNA - RDC1077 from R&D Systems

Prices $799.00
Sizes 10 µg
Species Mouse

Human LRP-5 (NP_002326) VersaClone cDNA - RDC1013 from R&D Systems

Prices $799.00
Sizes 10 µg
Species Human

Human LRP5 ORF clone(NM_002335.2) - CDCH388067 from Creative Biomart

Species Human
Accession NM_002335.2

Human LRP5 ORF clone (NM_002335.2) - CDCL128417 from Creative biogene

Species Human
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