LRP5

Gene Symbol	LRP5
Entrez Gene	4041
Alt Symbol	BMND1, EVR1, EVR4, HBM, LR3, LRP-5, LRP7, OPPG, OPS, OPTA1, VBCH2
Species	Human
Gene Type	protein-coding
Description	low density lipoprotein receptor-related protein 5
Other Description	low density lipoprotein receptor-related protein 7|low-density lipoprotein receptor-related protein 5
Swissprots	Q9UES7 Q9UP66 Q96TD6 O75197
Accessions	AAK52433 EAW74705 EAW74706 O75197 AA279383 AA953315 AB017498 BAA33051 AF064548 AAC36467 AF077820 AAC72791 AF088027 AI583742 BC098397 BC150595 AAI50596 DN999254 XM_005273994 XP_005274051 XM_011545029 XP_011543331 XM_011545030 XP_011543332 XM_011545031 XP_011543333 XR_949925 XR_949926 NM_001291902 NP_001278831 NM_002335 NP_002326
Function	Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor- ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3- mediated phosphorylation and destruction of beta-catenin. Appears be required for postnatal control of vascular regression in the eye. Required for posterior patterning of the epiblast during gastrulation. {ECO:0000269|PubMed:11336703, ECO:0000269|PubMed:11448771, ECO:0000269|PubMed:14727154, ECO:0000269|PubMed:14731402, ECO:0000269|PubMed:15778503}.
Subcellular Location	Membrane; Single-pass type I membrane protein. Endoplasmic reticulum {ECO:0000250}. Note=Chaperoned to the plasma membrane by MESD. {ECO:0000250}.
Tissue Specificity	Widely expressed, with the highest level of expression in the liver and in aorta. {ECO:0000269|PubMed:9790987}.
Top Pathways	Wnt signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human LRP5 protein fragment - ab114399 from Abcam Category Protein Source Wheat germ Species Human

LRP5 peptide (1178-1189) - ab45741 from Abcam Category Peptide Species Human

LRP5 Antibody Blocking Peptide - LS-E3470 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

LRP5 Antibody Blocking Peptide - LS-E8098 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

LRP5 Antibody Blocking Peptide - LS-E25886 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human LRP-5 Protein - H00004041-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

LRP-5 Peptide - P1764 from Novus Biologicals Category Peptide Species Human

LRP5-Antibody-C-term-Blocking-Peptide - BP14655b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

LRP5-Antibody-C-term-Blocking-Peptide - BP6157a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

LRP5 blocking peptide - GTX89521-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Rat

LRP 5/6 Blocking Peptide - 33R-10551 from Fitzgerald Category Peptide Prices $295.00 Sizes 50 µg

LRP 5/6 Blocking Peptide - 33R-10918 from Fitzgerald Category Peptide Prices $145.00 Sizes 50 µg

LRP 5/6 Blocking Peptide - 33R-10901 from Fitzgerald Category Peptide Prices $145.00 Sizes 50 µg

LRP 5/6 Blocking Peptide - 33R-10547 from Fitzgerald Category Peptide Prices $295.00 Sizes 50 µg

Human LRP5 Protein - abx067821 from Abbexa Category Protein Source E.coli Species Human

LRP5 Peptide - AC21-0715-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

LRP5 - H00004041-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

LRP5 - H00004041-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Low Density Lipoprotein Receptor Related Protein - 20-8681 from ARP American Research Products Category Protein Prices $529.00 Sizes 50 µg Source E.coli Species Human

LRP5 Peptide - 45-846P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

LRP5 fusion protein - ag19034 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

LRP5 fusion protein - ag20043 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human LRP5 - LRP5-29428TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Low Density Lipoprotein Receptor Related Protein 5 (LRP5) - RPD102Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Low Density Lipoprotein Receptor Related Protein 5 (LRP5) - RPD102Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

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