VRK1

Gene Symbol	VRK1
Entrez Gene	7443
Alt Symbol	PCH1, PCH1A
Species	Human
Gene Type	protein-coding
Description	vaccinia related kinase 1
Other Description	serine/threonine-protein kinase VRK1|vaccinia virus B1R-related kinase 1|vaccinia-related kinase 1
Swissprots	Q99986 Q3SYL2
Accessions	EAW81653 EAW81654 Q99986 AB000449 BAA19108 AK290110 BAF82799 BC005970 BC103761 AAI03762 BC112075 AAI12076 BC113510 AAI13511 BU535261 CA436761 XM_006720247 XP_006720310 XM_011537132 XP_011535434 NM_003384 NP_003375
Function	Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates 'Thr- 18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. Phosphorylates ATF2 which activates its transcriptional activity. {ECO:0000269|PubMed:10951572, ECO:0000269|PubMed:14645249, ECO:0000269|PubMed:15105425, ECO:0000269|PubMed:16495336, ECO:0000269|PubMed:18617507, ECO:0000269|PubMed:19103756}.
Subcellular Location	Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Note=Dispersed throughout the cell but not located on mitotic spindle or chromatids during mitosis.
Tissue Specificity	Widely expressed. Highly expressed in fetal liver, testis and thymus. {ECO:0000269|PubMed:9344656}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human VRK1 ELISA Kit (Sandwich ELISA) - LS-F6813 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.061 ng/ml Range 0.156-10 ng/ml

Vaccinia Related Kinase 1 (VRK1), Human, ELISA Kit - SEC600Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.062ng/mL Range 0.156-10ng/mL

VRK1 (Human) IP-WB Antibody Pair - H00007443-PW2 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

VRK1 (Human) Matched Antibody Pair - H00007443-AP51 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

Vaccinia Related Kinase 1, ELISA Kit - MBS096275 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Vaccinia Related Kinase 1, ELISA Kit - MBS057962 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Vaccinia Related Kinase 1, ELISA Kit - MBS050572 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Vaccinia Related Kinase 1, ELISA Kit - MBS090321 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

vaccinia related kinase 1, ELISA Kit - MBS9338835 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Vaccinia Related Kinase 1, ELISA Kit - MBS097756 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Vaccinia Related Kinase 1, ELISA Kit - MBS085469 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Vaccinia Related Kinase 1, ELISA Kit - MBS100336 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Vaccinia Related Kinase 1 (VRK1), ELISA Kit - MBS2021857 from MyBioSource Category ELISA Kit Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.061ng/mL. Range 0.156-10ng/mL

ELISA Kit for Vaccinia Related Kinase 1 (VRK1) - SEC600Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.061ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

ELISA Kit for Vaccinia Related Kinase 1 (VRK1) - SEC600Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.061ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human Vaccinia Related Kinase 1 (VRK1) ELISA Kit - EKU08068 from Biomatik Category ELISA Kit Prices $735.00, $3,234.00, $5,880.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 0.061 ng/mL Range 0.156-10 ng/mL

Human VRK1 ELISA Kit - abx153490 from Abbexa Category ELISA Kit Sensitivity 0.062 ng/ml Range 0.156 ng/ml - 10 ng/ml

Vaccinia Related Kinase 1 (VRK1), Human, ELISA Kit - DL-VRK1-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 0.156-10 ng/mL

Human VRK1 ELISA Kit - abx570803 from Abbexa Category ELISA Kit Sensitivity 0.062 ng/ml Range 0.156 ng/ml - 10 ng/ml

Human VRK1 ELISA Kit - E102717 from Biobool Category ELISA Kit

VRK1 ELISA Kit (Human) (OKCD00339) - OKCD00339 from Aviva Systems Biology Category ELISA Kit Prices $545.00 Sizes 96 wells Sensitivity < 0.061 ng/mL Range 0.156-10 ng/mL

VRK1 ELISA Kit (Human) (OKDD00592) - OKDD00592 from Aviva Systems Biology Category ELISA Kit Prices $580.00 Sizes 96 wells Sensitivity < 0.062 ng/mL Range 0.156-10 ng/mL

anti-VRK1 antibody - ARG55010 from Arigo Biolaboratories Category ELISA Kit

Human Serine/threonine-protein kinase VRK1 (VRK1) ELISA Kit - AE11538HU from ARP American Research Products Category ELISA Kit Prices $549.00 Sizes 96 t Sensitivity 0.061 ng/mL Range 0.156-10 ng/mL

Vaccinia Related Kinase 1 (VRK1), ELISA Kit - MBS453035 from MyBioSource Category ELISA Kit Prices $415.00, $550.00, $2,425.00, $4,710.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity <0.062ng/mL Range 0.156-10ng/mL

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