VRK1

Gene Symbol	VRK1
Entrez Gene	7443
Alt Symbol	PCH1, PCH1A
Species	Human
Gene Type	protein-coding
Description	vaccinia related kinase 1
Other Description	serine/threonine-protein kinase VRK1|vaccinia virus B1R-related kinase 1|vaccinia-related kinase 1
Swissprots	Q99986 Q3SYL2
Accessions	EAW81653 EAW81654 Q99986 AB000449 BAA19108 AK290110 BAF82799 BC005970 BC103761 AAI03762 BC112075 AAI12076 BC113510 AAI13511 BU535261 CA436761 XM_006720247 XP_006720310 XM_011537132 XP_011535434 NM_003384 NP_003375
Function	Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates 'Thr- 18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. Phosphorylates ATF2 which activates its transcriptional activity. {ECO:0000269|PubMed:10951572, ECO:0000269|PubMed:14645249, ECO:0000269|PubMed:15105425, ECO:0000269|PubMed:16495336, ECO:0000269|PubMed:18617507, ECO:0000269|PubMed:19103756}.
Subcellular Location	Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Note=Dispersed throughout the cell but not located on mitotic spindle or chromatids during mitosis.
Tissue Specificity	Widely expressed. Highly expressed in fetal liver, testis and thymus. {ECO:0000269|PubMed:9344656}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human VRK1 full length protein - ab125555 from Abcam Category Protein Prices $239.00, $1,845.00 Sizes 5 µg, 100 µg Source Baculovirus infected sf9 cells Species Human

Human VRK1 protein fragment - ab94032 from Abcam Category Protein Source E. coli Species Human

VRK1 Antibody Blocking Peptide - LS-E8930 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human VRK1 Protein - H00007443-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

VRK1 Partial Recombinant Protein - H00007443-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

VRK1 Recombinant Protein - P4795 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Species Human

VRK1 Peptide - P2495 from Novus Biologicals Category Peptide Species Human

VRK1-Antibody-Center-Blocking-Peptide - BP7408c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human PCH1 protein - orb139872 from Biorbyt Category Protein Prices $570.00, $663.00 Sizes 20 μg, 50 μg Source Baculovirus-Insect Cells Species Human

Human PCH1 protein - orb139871 from Biorbyt Category Protein Prices $323.00, $646.00 Sizes 20 μg, 100 μg Source Baculovirus-Insect Cells Species Human

Human VRK1 Protein - abx069616 from Abbexa Category Protein Source E.coli Species Human

VRK1 - H00007443-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

VRK1 - H00007443-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

VRK1 - H00007443-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

VRK1 - H00007443-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

VRK1 - P4795 from Acris Antibodies Category Protein Prices $1,380.00 Sizes 100 µg Species Human

VRK1 - P5776 from Acris Antibodies Category Protein Prices $790.00 Sizes 5 µg Species Human

Vaccinia Related Kinase 1 (VRK1), Human - 20-8540 from ARP American Research Products Category Protein Prices $517.00 Sizes 50 µg Source E.coli Species Human

VRK1 fusion protein - ag12544 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant VRK1 protein - 31243 from ActiveMotif Category Protein Prices $390.00 Sizes 10 µg Source E. coli Species Human

Recombinant VRK1 protein - 31200 from ActiveMotif Category Protein Prices $390.00 Sizes 10 µg Source Baculovirus Species Human

Recombinant Human Vaccinia Related Kinase 1, GST-His - VRK1-706H from Creative Biomart Category Protein Source Baculovirus infected Sf9 cells.

Recombinant Human VRK1, His-tagged - VRK1-31740TH from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human VRK1, Gly & Pro tagged - VRK1-520H from Creative Biomart Category Protein Source Baculovirus-Insect cells Species Human

Recombinant Human Vaccinia Related Kinase 1, GST-tagged - VRK1-1117H from Creative Biomart Category Protein Species Human

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