VRK1

Gene Symbol	VRK1
Entrez Gene	7443
Alt Symbol	PCH1, PCH1A
Species	Human
Gene Type	protein-coding
Description	vaccinia related kinase 1
Other Description	serine/threonine-protein kinase VRK1|vaccinia virus B1R-related kinase 1|vaccinia-related kinase 1
Swissprots	Q99986 Q3SYL2
Accessions	EAW81653 EAW81654 Q99986 AB000449 BAA19108 AK290110 BAF82799 BC005970 BC103761 AAI03762 BC112075 AAI12076 BC113510 AAI13511 BU535261 CA436761 XM_006720247 XP_006720310 XM_011537132 XP_011535434 NM_003384 NP_003375
Function	Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates 'Thr- 18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. Phosphorylates ATF2 which activates its transcriptional activity. {ECO:0000269|PubMed:10951572, ECO:0000269|PubMed:14645249, ECO:0000269|PubMed:15105425, ECO:0000269|PubMed:16495336, ECO:0000269|PubMed:18617507, ECO:0000269|PubMed:19103756}.
Subcellular Location	Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Note=Dispersed throughout the cell but not located on mitotic spindle or chromatids during mitosis.
Tissue Specificity	Widely expressed. Highly expressed in fetal liver, testis and thymus. {ECO:0000269|PubMed:9344656}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PCH1 Gene - orb92408 from Biorbyt Prices $255.00 Sizes 10 μg Species Human

Human-VRK1-cDNA-Clone - DC09799 from Abgent, a WuXi AppTec company Prices $535.95 Sizes 10 µg Species Human Accession NM_003384

VRK1 - MBS1274379 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC113510

Human TLK2 ORF clone(NM_003384.2) - CDCL186465 from Creative Biomart Species Human Accession NM_003384.2

Human VRK1 cDNA clone(NM_003384.2) - CDFH021143 from Creative Biomart Species Human Accession NM_003384.2

Human VRK1 cDNA clone(NM_003384.2) - CDFH021144 from Creative Biomart Species Human Accession NM_003384.2

Human VRK1 ORF Clone(NM_003384.2) - CDCR285500 from Creative Biomart Species Human Accession NM_003384.2

Human VRK1 ORF Clone(NM_003384.2) - CDCR285501 from Creative Biomart Species Human Accession NM_003384.2

Human VRK1 ORF Clone(NM_003384.2) - CDCR285502 from Creative Biomart Species Human Accession NM_003384.2

Human VRK1 ORF clone(NM_003384.2) - CDCL186744 from Creative Biomart Species Human Accession NM_003384.2

human VRK1 ORF clone - CDCH100298 from Creative Biomart Species Human Accession NM_003384

human VRK1 ORF clone - CDCH100299 from Creative Biomart Species Human Accession NM_003384

Human VRK1 ORF Clone(NM_003384.2) - CDCL181011 from Creative Biomart Species Human Accession NM_003384.2

Human TLK2/PKU-ALPHA transcript variant B Gene ORF cDNA clone expression plasmid, C-Flag tag - HG11551-M-F from Sino Biological Species Human

Human VRK1 Gene cDNA clone plasmid - HG11555-M from Sino Biological Species Human

Human VRK1 Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG11555-ANR from Sino Biological Species Human

Human VRK1 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG11555-CM from Sino Biological Species Human

Human VRK1 Gene ORF cDNA clone expression plasmid - HG11555-UT from Sino Biological Species Human

Human VRK1 Gene ORF cDNA clone expression plasmid, N-HA tag - HG11555-NY from Sino Biological Species Human

Human VRK1 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG11555-ANG from Sino Biological Species Human

Human VRK1 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG11555-ACG from Sino Biological Species Human

Human VRK1 Gene ORF cDNA clone expression plasmid, N-His tag - HG11555-NH from Sino Biological Species Human

Human VRK1 Gene ORF cDNA clone expression plasmid, C-HA tag - HG11555-CY from Sino Biological Species Human

Human VRK1 Gene ORF cDNA clone expression plasmid, C-His tag - HG11555-CH from Sino Biological Species Human

Human VRK1 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG11555-NF from Sino Biological Species Human

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