VRK1

Gene Symbol	VRK1
Entrez Gene	7443
Alt Symbol	PCH1, PCH1A
Species	Human
Gene Type	protein-coding
Description	vaccinia related kinase 1
Other Description	serine/threonine-protein kinase VRK1|vaccinia virus B1R-related kinase 1|vaccinia-related kinase 1
Swissprots	Q99986 Q3SYL2
Accessions	EAW81653 EAW81654 Q99986 AB000449 BAA19108 AK290110 BAF82799 BC005970 BC103761 AAI03762 BC112075 AAI12076 BC113510 AAI13511 BU535261 CA436761 XM_006720247 XP_006720310 XM_011537132 XP_011535434 NM_003384 NP_003375
Function	Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates 'Thr- 18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. Phosphorylates ATF2 which activates its transcriptional activity. {ECO:0000269|PubMed:10951572, ECO:0000269|PubMed:14645249, ECO:0000269|PubMed:15105425, ECO:0000269|PubMed:16495336, ECO:0000269|PubMed:18617507, ECO:0000269|PubMed:19103756}.
Subcellular Location	Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Note=Dispersed throughout the cell but not located on mitotic spindle or chromatids during mitosis.
Tissue Specificity	Widely expressed. Highly expressed in fetal liver, testis and thymus. {ECO:0000269|PubMed:9344656}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

VRK1-Over-expression-Lysate - LY10667a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

VRK1 293T Cell Transient Overexpression Lysate(Denatured) - H00007443-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

VRK1 overexpression lysate - LY418719 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

VRK1 293 Cell Lysate - 408739 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

VRK1 Overexpression Lysate (Denatured) - H00007443-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

VRK1 Overexpression Lysate (Native) - NBL1-17759 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

VRK1 (h): 293T Lysate - sc-111736 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

VRK1 Over-expression Lysate Product - GWB-CAF223 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Human VRK1 Insect Cell Lysate (WB positive control) - 11555-HNCBL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human VRK1 Insect Cell Lysate (WB positive control) - 11555-H20BL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

VRK1 Overexpression Lysate (Denatured) - H00007443-T02 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

Human VRK1 Baculovirus-Insect Cells Transfected Lysate Baculovirus-Insect Cells Transfected Lysate (positive control) (denatured) - orb175266 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

Human VRK1 Baculovirus-Insect Cells Transfected Lysate Baculovirus-Insect Cells Transfected Lysate (positive control) (denatured) - orb175173 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

Panoply™ Human VRK1 Knockdown Stable Cell Line - CSC-DC017334 from Creative biogene Category Cell Line Species Human

VRK1 KO Cell Lysate-HEK293T - CLKO-0714 from Creative biogene Category Cell Lysate

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