VRK1

Gene Symbol	VRK1
Entrez Gene	7443
Alt Symbol	PCH1, PCH1A
Species	Human
Gene Type	protein-coding
Description	vaccinia related kinase 1
Other Description	serine/threonine-protein kinase VRK1|vaccinia virus B1R-related kinase 1|vaccinia-related kinase 1
Swissprots	Q99986 Q3SYL2
Accessions	EAW81653 EAW81654 Q99986 AB000449 BAA19108 AK290110 BAF82799 BC005970 BC103761 AAI03762 BC112075 AAI12076 BC113510 AAI13511 BU535261 CA436761 XM_006720247 XP_006720310 XM_011537132 XP_011535434 NM_003384 NP_003375
Function	Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates 'Thr- 18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. Phosphorylates ATF2 which activates its transcriptional activity. {ECO:0000269|PubMed:10951572, ECO:0000269|PubMed:14645249, ECO:0000269|PubMed:15105425, ECO:0000269|PubMed:16495336, ECO:0000269|PubMed:18617507, ECO:0000269|PubMed:19103756}.
Subcellular Location	Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Note=Dispersed throughout the cell but not located on mitotic spindle or chromatids during mitosis.
Tissue Specificity	Widely expressed. Highly expressed in fetal liver, testis and thymus. {ECO:0000269|PubMed:9344656}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

VRK1 CRISPR/Cas9 KO Plasmid (h) - sc-404617 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

VRK1 HDR Plasmid (h) - sc-404617-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

VRK1 Double Nickase Plasmid (h) - sc-404617-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

VRK1 Double Nickase Plasmid (h2) - sc-404617-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

VRK1 CRISPR Activation Plasmid (h) - sc-404617-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

VRK1 CRISPR Activation Plasmid (h2) - sc-404617-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

VRK1 Lentiviral Activation Particles (h) - sc-404617-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

VRK1 Lentiviral Activation Particles (h2) - sc-404617-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

VRK1 siRNA (h) - sc-106702 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

VRK1 shRNA Plasmid (h) - sc-106702-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

VRK1 shRNA (h) Lentiviral Particles - sc-106702-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

VRK1 RNAi - H00007443-R01V from Novus Biologicals Category siRNA Prices $629.00 Sizes 20 nmol Species Reactivities Human

VRK1 RNAi - H00007443-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU119541 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK2449 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK2450 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK2451 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN2155 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2155 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR02981 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr02981

VRK1 siRNA (Human) - CRH5093 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

VRK1 - MBS8219323 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human VRK1 (NM_003384.2) - SHH445144 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human VRK1(NM_003384.2) - SHL128502 from Creative biogene Category siRNA Species Reactivities Human

Human VRK1 siRNA - orb265595 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

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