MKNK1

Gene Symbol MKNK1
Entrez Gene 8569
Alt Symbol MNK1
Species Human
Gene Type protein-coding
Description MAP kinase interacting serine/threonine kinase 1
Other Description MAP kinase signal-integrating kinase 1|MAP kinase-interacting serine/threonine-protein kinase 1|MAPK signal-integrating kinase 1
Swissprots D3DQ21 Q5TC07 O00312 Q6V0N6 Q5TC06 D3DQ20 Q9BUB5
Accessions EAX06900 EAX06901 EAX06902 EAX06903 EAX06904 EAX06905 Q9BUB5 AB000409 BAA19885 AB451300 BAG70114 AB451432 BAG70246 AK096423 BAG53286 AK290456 BAF83145 AK298839 BAG60967 AK304005 BAG64921 AK310566 AY355461 AAQ84219 BC002755 AAH02755 BG722049 BM665342 BX538193 CAD98062 BX648559 DA435648 DA502363 DC366212 DC376088 DQ892992 ABM83918 DQ896240 ABM87239 EU831624 ACE87224 EU831709 ACE86543 XM_006710999 XP_006711062 XM_006711000 XP_006711063 XM_006711001 XP_006711064 XM_006711002 XP_006711065 XM_006711003 XP_006711066 XM_006711004 XP_006711067 XM_006711005 XP_006711068 XM_006711006 XP_006711069 XM_006711007 XP_006711070 XM_006711008 XP_006711071 XM_006711009 XP_006711072 XM_006711010 XP_006711073 XM_006711013 XP_006711076 XM_006711014 XP_006711077 XM_006711015 XP_006711078 XM_011542349 XP_011540651 XM_011542350 XP_011540652 NM_001135553 NP_001129025 NM_003684 NP_003675 NM_198973 NP_945324 NR_024174 NR_024176 NR_024175
Function May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7- methylguanosine-containing mRNA cap. {ECO:0000269|PubMed:11463832, ECO:0000269|PubMed:15350534, ECO:0000269|PubMed:9155018, ECO:0000269|PubMed:9878069}.
Subcellular Location Isoform 2: Cytoplasm.
Tissue Specificity Ubiquitous. {ECO:0000269|PubMed:15350534}.
Top Pathways Insulin signaling pathway, MAPK signaling pathway

Phospho-Mnk1 (Thr197/202) Antibody - 2111 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from NIH/3T3 cells using Phospho-Mnk1 (Thr197/202) Antibody (upper) and Mnk1 (C4C1) Rabbit mAb #2195 (lower). The cells were starved for 24 hours in serum-free medium and then either untreated (-) or treated with serum for 30 minutes (+).

Mnk1 (C4C1) Rabbit mAb - 2195 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone C4C1
Western blot analysis of extracts from various cell lines using Mnk1 (C4C1) Rabbit mAb.

Mnk1 (C-5) - sc-133108 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Mnk1 (C-5): sc-133108. Western blot analysis of Mnk1 expression in HeLa (A), K-562 (B) and 3611-RF (C) whole cell lysates.

Mnk1 (C-20) - sc-6965 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Mnk1 (C-20): sc-6965. Western blot analysis of Mnk1 expression in non-transfected: sc-117752 (A) and human Mnk1 transfected: sc-171267 (B) 293T whole cell lysates.

Mnk1 (D-2) - sc-133246 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Mnk1 (D-2): sc-133246. Western blot analysis of Mnk1 expression in HeLa (A) and K-562 (B) whole cell lysates.

Mnk1 (A-4) - sc-133107 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Mnk1 (A-4): sc-133107. Western blot analysis of Mnk1 expression in HeLa (A), K-562 (B) and 3611-RF (C) whole cell lysates.

Mnk1 (G-19) - sc-6961 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Mnk1 (G-19): sc-6961. Western blot analysis of Mnk1 expression in non-transfected: sc-117752 (A) and mouse Mnk1 transfected: sc-125627 (B) 293T whole cell lysates.

Mnk1 (H-55) - sc-28780 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Mnk1 (H-55): sc-28780. Western blot analysis of Mnk1 expression in non-transfected: sc-117752 (A) and human Mnk1 transfected: sc-171267 (B) 293T whole cell lysates.

Mnk1 (M-20) - sc-6962 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Mnk1 (M-20): sc-6962. Western blot analysis of Mnk1 expression in non-transfected: sc-117752 (A) and mouse Mnk1 transfected: sc-125627 (B) 293T whole cell lysates.

Anti-MNK1 (phospho T250) antibody - ab111434 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab111434, at 1/50 dilution, staining MNK1 in paraffin-embedded Human breast carcinoma tissue by Immunohistochemistry, in the presence (right panel) or absence (left panel) of immunising peptide.

Anti-MNK1 (phospho T385) antibody - ab138671 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-MNK1 (phospho T385) antibody (ab138671) at 1/500 dilution + COLO205 cell lysate (from cells treated with 125 ng/ml PMA for 30 minutes) at 30 µg

Anti-MNK1 (phospho T385) antibody [EPR2370] - ab109102 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2370
All lanes : Anti-MNK1 (phospho T385) antibody [EPR2370] (ab109102) at 1/1000 dilutionLane 1 : HeLa cell lysate, untreatedLane 2 : HeLa cell lysate, treated with Calyculin A.Lysates/proteins at 10 µg per lane.

Anti-MNK1 antibody - ab89223 from Abcam

Prices $387.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Anti-MNK1 antibody (ab89223) at 5 µg/ml + immunogen at 0.2 µgdeveloped using the ECL technique

Anti-MNK1 antibody - ab79365 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-MNK1 antibody (ab79365) at 1/500 dilutionLane 1 : 3T3 cell extractsLane 2 : 3T3 cell extracts with immunising peptide at 10 µgLysates/proteins at 30 µg per lane.

Anti-MNK1 antibody - ab111292 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry analysis of paraffin-embedded Human breast carcinoma tissue, using ab111292 at a dilution of 1/50. Left panel shows staining without immunizing peptide right panel shows staining with immunizing peptide

Anti-MNK1 antibody - ab196947 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-MNK1 antibody (ab196947) at 1/500 dilutionLane 1 : 3T3 cell extract, treated with PMA (125ng/ml, 30mins)Lane 2 : 3T3 cell extract, treated with PMA (125ng/ml, 30mins) with synthesized peptide

Anti-MNK1 antibody - ab56425 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
MNK1 antibody (ab56425) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human placenta.

Anti-MNK1 antibody - ab56430 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
MNK1 antibody (ab56430) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human placenta.

Anti-MNK1 antibody - ab60204 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-MNK1 antibody (ab60204) at 1/100 dilution + A2058 tissue lysate

Anti-MNK1 antibody - ab65106 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-MNK1 antibody (ab65106) at 1/500 dilutionLane 1 : Extracts from HuvEc cellsLane 2 : Extracts from HuvEc cells with immunising peptide at 5 µgLysates/proteins at 5 µg per lane.

Anti-MNK1 antibody [24C2] - ab70834 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 24C2
All lanes : Anti-MNK1 antibody [24C2] (ab70834) at 1/1000 dilutionLane 1 : HeLa cell lysateLane 2 : MCF-7 cell lysateLane 3 : NIH3T3 cell lysateLane 4 : H9C2 cell lysate

Anti-MNK1 antibody [2F12] - ab189150 from Abcam

Prices $384.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 2F12
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human tonsil tissue labeling MNK1 with ab189150 at 5 µg/ml.

Anti-MNK1 antibody [2H8] - ab117545 from Abcam

Prices $384.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 2H8
ab115457, at 5 µg/ml, staining MNK1 in Formalin-fixed, Paraffin-embedded Human Tonsil tissue by Immunohistochemistry.

Anti-MKNK1 / MNK1 Antibody (phospho-Thr197/Thr202) - LS-C16582 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-MKNK1 / MNK1 Antibody (aa351-400) - LS-C118364 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from NIH-3T3 cells, treated with PMA 125 ng/ml 30', using Mnk1 (Ab-385) Antibody. The lane on the right is treated with the synthesized peptide.
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