| Gene Symbol |
PGF
|
| Entrez Gene |
5228
|
| Alt Symbol |
D12S1900, PGFL, PLGF, PlGF-2, SHGC-10760
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
placental growth factor
|
| Other Description |
placenta growth factor|placental growth factor, vascular endothelial growth factor-related protein
|
| Swissprots |
Q9Y6S8 Q9BV78 Q07101 P49763
|
| Accessions |
AAB25832 AAD30179 ABY87550 AGC09600 CAH23419 CAI84580 CAJ32891 CAL32761 CBH30536 EAW81207 EAW81208 EAW81209 P49763 A18411 CAA01393 AK023843 AK309886 AK310608 AK310886 AL543693 BC001422 AAH01422 BC007255 AAH07255 BC007789 AAH07789 BT007182 AAP35846 BX248289 CAD62617 BX356823 DQ892136 ABM83062 DQ895330 ABM86256 S72960 AAB30462 X54936 CAA38698 NM_001207012 NP_001193941 NM_001293643 NP_001280572 NM_002632 NP_002623
|
| Function |
Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth. {ECO:0000269|PubMed:21215706}.
|
| Subcellular Location |
Secreted. Note=The three isoforms are secreted but PlGF-2 appears to remain cell attached unless released by heparin.
|
| Tissue Specificity |
While the three isoforms are present in most placental tissues, PlGF-2 is specific to early (8 week) placenta and only PlGF-1 is found in the colon and mammary carcinomas.
|
| Top Pathways |
Focal adhesion, PI3K-Akt signaling pathway, Rap1 signaling pathway
|
