PGF

Gene Symbol	PGF
Entrez Gene	5228
Alt Symbol	D12S1900, PGFL, PLGF, PlGF-2, SHGC-10760
Species	Human
Gene Type	protein-coding
Description	placental growth factor
Other Description	placenta growth factor|placental growth factor, vascular endothelial growth factor-related protein
Swissprots	Q9Y6S8 Q9BV78 Q07101 P49763
Accessions	AAB25832 AAD30179 ABY87550 AGC09600 CAH23419 CAI84580 CAJ32891 CAL32761 CBH30536 EAW81207 EAW81208 EAW81209 P49763 A18411 CAA01393 AK023843 AK309886 AK310608 AK310886 AL543693 BC001422 AAH01422 BC007255 AAH07255 BC007789 AAH07789 BT007182 AAP35846 BX248289 CAD62617 BX356823 DQ892136 ABM83062 DQ895330 ABM86256 S72960 AAB30462 X54936 CAA38698 NM_001207012 NP_001193941 NM_001293643 NP_001280572 NM_002632 NP_002623
Function	Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth. {ECO:0000269|PubMed:21215706}.
Subcellular Location	Secreted. Note=The three isoforms are secreted but PlGF-2 appears to remain cell attached unless released by heparin.
Tissue Specificity	While the three isoforms are present in most placental tissues, PlGF-2 is specific to early (8 week) placenta and only PlGF-1 is found in the colon and mammary carcinomas.
Top Pathways	Focal adhesion, PI3K-Akt signaling pathway, Rap1 signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human PLGF full length protein - ab174025 from Abcam Category Protein Prices $414.00 Sizes 20 µg Source HEK 293 cells Species Human

Active human PLGF protein fragment - ab73241 from Abcam Category Protein Prices $315.00 Sizes 10 µg Source Insect cells Species Human

Active human PLGF2 full length protein - ab70668 from Abcam Category Protein Prices $257.00 Sizes 10 µg Source E. coli Species Human

Human PLGF full length protein - ab84148 from Abcam Category Protein Source HEK 293 cells Species Human

Human PLGF full length protein - ab195081 from Abcam Category Protein Source HEK 293 cells Species Human

Human PLGF peptide - ab95428 from Abcam Category Peptide

Human PLGF protein fragment - ab159102 from Abcam Category Protein Source Wheat germ Species Human

Human PLGF1 full length protein - ab50127 from Abcam Category Protein Source E. coli Species Human

Human PLGF1 full length protein - ab54336 from Abcam Category Protein Species Human

Mouse PLGF full length protein - ab194182 from Abcam Category Protein Source HEK 293 cells Species Mouse

Rat PLGF full length protein - ab190989 from Abcam Category Protein Source E. coli Species Rat

PGF / PLGF Antibody Blocking Peptide - LS-E3402 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PGF / PLGF Antibody Blocking Peptide - LS-E27157 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PlGF Partial Recombinant Protein - H00005228-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

PlGF Recombinant Protein - P4132 from Novus Biologicals Category Protein Prices $549.00 Sizes 10 µg Species Human

PlGF Recombinant Protein - P4131 from Novus Biologicals Category Protein Prices $549.00 Sizes 25 µg Species Human

Recombinant Human PLGF Protein - NBP1-99298 from Novus Biologicals Category Protein Prices $180.00 Sizes 10 µg Source E. coli Species Human

Recombinant Human PLGF-1 Protein - NBP1-99284 from Novus Biologicals Category Protein Prices $180.00, $799.00, $3,999.00 Sizes 25 µg, 100 µg, 1 mg Source E. coli Species Human

PlGF Protein - NBP1-99743 from Novus Biologicals Category Protein Species Human

PlGF Protein - NBP1-99734 from Novus Biologicals Category Protein Species Human

PGF-Antibody-Center-Blocking-Peptide - BP14578c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PLGF-1 recombinant protein - GTX65200 from GeneTex Category Protein Prices $249.00 Sizes 25 μg Source E. coli Species Human

PlGF-1 Recombinant Protein (Active) - GTX48384-PRO from GeneTex Category Protein Prices $299.00 Sizes 25 μg Source E. coli Species Human

PlGF-1 Recombinant Protein (Active) - GTX48386-PRO from GeneTex Category Protein Prices $299.00 Sizes 25 μg Source E. coli Species Human

PlGF-2 recombinant protein - GTX53850 from GeneTex Category Protein Prices $199.00 Sizes 25 μg Source E. Coli

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