TNFRSF1A

Gene Symbol TNFRSF1A
Entrez Gene 7132
Alt Symbol CD120a, FPF, MS5, TBP1, TNF-R, TNF-R-I, TNF-R55, TNFAR, TNFR1, TNFR1-d2, TNFR55, TNFR60, p55, p55-R, p60
Species Human
Gene Type protein-coding
Description tumor necrosis factor receptor superfamily, member 1A
Other Description TNF-R1|TNF-RI|TNFR-I|tumor necrosis factor binding protein 1|tumor necrosis factor receptor 1A isoform beta|tumor necrosis factor receptor superfamily member 1A|tumor necrosis factor receptor type 1|tumor necrosis factor-alpha receptor
Swissprots D3DUR1 B4DQB7 B4E309 P19438 B2RDE4 B3KPQ1 B5M0B5 Q9UCA4 A8K4X3
Accessions AAA61201 AAM77802 CAI84622 CCA94574 EAW88805 EAW88806 P19438 A21522 CAA01558 AK056611 BAG51763 AK130807 AK291088 BAF83777 AK298729 BAG60879 AK304517 BAG65321 AK308061 AK315509 BAG37891 AY182755 AAO23979 BC010140 AAH10140 BF528949 DA664652 EU176385 ABW03836 EU176726 ABW03527 EU927389 ACH57451 JN172914 AEO89726 M33294 AAA03210 M58286 AAA36753 M60275 AAA36756 M63121 AAA36754 NM_001065 NP_001056
Function Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate- specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
Subcellular Location Cell membrane {ECO:0000269|PubMed:22801493}; Single-pass type I membrane protein {ECO:0000269|PubMed:22801493}. Golgi apparatus membrane {ECO:0000269|PubMed:22801493}; Single- pass type I membrane protein {ECO:0000269|PubMed:22801493}. Secreted {ECO:0000269|PubMed:22801493}. Note=A secreted form is produced through proteolytic processing.
Top Pathways Sphingolipid signaling pathway, Herpes simplex infection, TNF signaling pathway, Non-alcoholic fatty liver disease (NAFLD), Tuberculosis

TNF-R1 (C25C1) Rabbit mAb - 3736 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone C25C1
Western blot analysis of extracts from A549, LN-18 and HeLa cells using TNF-R1 (C25C1) Rabbit mAb.

TNF-R1 (G-17) - sc-31351 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

TNF-R1 (G-20) - sc-1069 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TNF-R1 (G-20): sc-1069. Western blot analysis of human (A) and mouse (B) recombinant soluble TNF-R1.

TNF-R1 (H-5) - sc-8436 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TNF-R1 siRNA (h): sc-29507. Western blot analysis of TNF-R1 expression in non-transfected control (A) and TNF-R1 siRNA transfected (B) HeLa cells. Blot probed with TNF-R1 (H-5): sc-8436. GAPDH (FL-335): sc-25778 used as specificity and loading control.

TNF-R1 (H-271) - sc-7895 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
TNF-R1 (H-271): sc-7895. Western blot analysis of TNF-R1 expression in non-transfected: sc-117752 (A) and mouse TNF-R1 transfected: sc-124202 (B) 293T whole cell lysates.

TNF-R1 (K-20) - sc-31349 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TNF-R1 (K-20): sc-31349. Western blot analysis of TNF-R1 expression in HeLa whole cell lysate.

TNF-R1 (N-20) - sc-1067 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TNF-R1 (N-20): sc-1067. Western blot analysis of TNF-R1 expression in non-transfected: sc-117752 (A) and mouse TNF-R1 transfected: sc-124202 (B) 293T whole cell lysates.

TNF-R1 (S-20) - sc-31350 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TNF-R1 (S-20): sc-31350. Western blot analysis of TNF-R1 expression in THP-1 whole cell lysate.

TNF-R1 (C-20) - sc-1068 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TNF-R1 Antibody (C-20): sc-1068. Immunoperoxidase staining of formalin fixed, paraffin-embedded human lower stomach tissue showing cytoplasmic staining of glandular cells.

TNF-R1 (55R-170) - sc-12746 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Hamster
Clonality Monoclonal
TNF-R1 (55R-170) PE: sc-12746 PE. FCM analysis of mouse peripheral blood leukocytes. Black line histogram represents the isotype control, normal Armenian hamster IgG: sc-2875.

TNF-R1 (H398) - sc-52739 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
TNF-R1 (H398): sc-52739. Western blot analysis of TNF-R1 expression in 293T whole cell lysate.

p-TNF-R1 (Ser 274) - sc-130220 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
p-TNF-R1 (Ser 274): sc-130220. Western blot analysis of p-TNF-R1 expression in mouse uterus tissue extract.

Anti-Soluble TNF Receptor I antibody - ab34842 from Abcam

Prices $370.00
Sizes 500 µl
Host Rabbit
Clonality Polyclonal

Anti-soluble TNF Receptor I antibody - ab9979 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-soluble TNF Receptor I antibody - ab28749 from Abcam

Prices $359.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Anti-soluble TNF Receptor I antibody (ab28749) + Human Liver Lysate at 1 µg/mlObserved band size : 28 kDa (why is the actual band size different from the predicted?)

Anti-Soluble TNF Receptor I antibody [MM0572-5D31] - ab89876 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone MM0572-5D31

Anti-TNF Receptor I (phospho S274) antibody - ab60031 from Abcam

Prices $313.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with ab60031 at a dilution of 1/50. A peroxidase-conjugated secondary antibody was used, followed by AEC staining.

Anti-TNF Receptor I antibody - ab58436 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab58436, at 1/50 dilution, staining TNF Receptor I in paraffin embedded human breast carcinoma tissue by Immunohistochemistry in the absence (left image) or presence (right image) of the immunising peptide.

Anti-TNF Receptor I antibody - ab90121 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-TNF Receptor I antibody (ab90121) at 1 µg/ml (in 5% skim milk / PBS buffer) + DU145 cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-TNF Receptor I antibody - ab7743 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-TNF Receptor I antibody [EP1651AY] - ab68160 from Abcam

Prices $381.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP1651AY
Anti-TNF Receptor I antibody [EP1651AY] (ab68160) at 1/500 dilution + human brain tissue lysate at 10 µgSecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-TNF Receptor I antibody [H398] - ab2257 from Abcam

Prices $378.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone H398

Anti-TNF Receptor I antibody [H398] - ab194814 from Abcam

Prices $372.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone H398

Anti-TNF Receptor I antibody [H398] (FITC) - ab25472 from Abcam

Prices $370.00
Sizes 50 tests
Host Mouse
Clonality Monoclonal
Clone H398

Anti-TNF Receptor I antibody [MR1-2] - ab8160 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone MR1-2
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