TNFRSF1A

Gene Symbol	TNFRSF1A
Entrez Gene	7132
Alt Symbol	CD120a, FPF, MS5, TBP1, TNF-R, TNF-R-I, TNF-R55, TNFAR, TNFR1, TNFR1-d2, TNFR55, TNFR60, p55, p55-R, p60
Species	Human
Gene Type	protein-coding
Description	tumor necrosis factor receptor superfamily, member 1A
Other Description	TNF-R1|TNF-RI|TNFR-I|tumor necrosis factor binding protein 1|tumor necrosis factor receptor 1A isoform beta|tumor necrosis factor receptor superfamily member 1A|tumor necrosis factor receptor type 1|tumor necrosis factor-alpha receptor
Swissprots	D3DUR1 B4DQB7 B4E309 P19438 B2RDE4 B3KPQ1 B5M0B5 Q9UCA4 A8K4X3
Accessions	AAA61201 AAM77802 CAI84622 CCA94574 EAW88805 EAW88806 P19438 A21522 CAA01558 AK056611 BAG51763 AK130807 AK291088 BAF83777 AK298729 BAG60879 AK304517 BAG65321 AK308061 AK315509 BAG37891 AY182755 AAO23979 BC010140 AAH10140 BF528949 DA664652 EU176385 ABW03836 EU176726 ABW03527 EU927389 ACH57451 JN172914 AEO89726 M33294 AAA03210 M58286 AAA36753 M60275 AAA36756 M63121 AAA36754 NM_001065 NP_001056
Function	Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate- specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:22801493}; Single-pass type I membrane protein {ECO:0000269|PubMed:22801493}. Golgi apparatus membrane {ECO:0000269|PubMed:22801493}; Single- pass type I membrane protein {ECO:0000269|PubMed:22801493}. Secreted {ECO:0000269|PubMed:22801493}. Note=A secreted form is produced through proteolytic processing.
Top Pathways	Sphingolipid signaling pathway, Herpes simplex infection, TNF signaling pathway, Non-alcoholic fatty liver disease (NAFLD), Tuberculosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® TNF-R1 siRNA I - 12941 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

TNF-R1 CRISPR/Cas9 KO Plasmid (h) - sc-400206 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

TNF-R1 HDR Plasmid (h) - sc-400206-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TNF-R1 Double Nickase Plasmid (h) - sc-400206-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TNF-R1 Double Nickase Plasmid (h2) - sc-400206-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TNF-R1 CRISPR Activation Plasmid (h) - sc-400206-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

TNF-R1 CRISPR Activation Plasmid (h2) - sc-400206-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

TNF-R1 Lentiviral Activation Particles (h) - sc-400206-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TNF-R1 Lentiviral Activation Particles (h2) - sc-400206-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TNF-R1 siRNA (h) - sc-29507 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

TNF-R1 shRNA Plasmid (h) - sc-29507-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

TNF-R1 shRNA (h) Lentiviral Particles - sc-29507-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

TNF RI/TNFRSF1A RNAi - H00007132-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU001001 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN21751 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21751 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

TNFRSF1A siRNA (Human) - CRH4891 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

TNFRSF1A - MBS8231091 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human TNFRSF1A (NM_001065.3) - SHH431980 from Creative biogene Category siRNA Species Reactivities Human

Human TNFRSF1A siRNA - orb265393 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

TNFRSF1A shRNA Plasmid (Human) - CHH4891 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

TNFRSF1A miRNA 3'UTR clone - MiUTR3H-02333 from Creative biogene Species Reactivities Human

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