TNFRSF1A

Gene Symbol	TNFRSF1A
Entrez Gene	7132
Alt Symbol	CD120a, FPF, MS5, TBP1, TNF-R, TNF-R-I, TNF-R55, TNFAR, TNFR1, TNFR1-d2, TNFR55, TNFR60, p55, p55-R, p60
Species	Human
Gene Type	protein-coding
Description	tumor necrosis factor receptor superfamily, member 1A
Other Description	TNF-R1|TNF-RI|TNFR-I|tumor necrosis factor binding protein 1|tumor necrosis factor receptor 1A isoform beta|tumor necrosis factor receptor superfamily member 1A|tumor necrosis factor receptor type 1|tumor necrosis factor-alpha receptor
Swissprots	D3DUR1 B4DQB7 B4E309 P19438 B2RDE4 B3KPQ1 B5M0B5 Q9UCA4 A8K4X3
Accessions	AAA61201 AAM77802 CAI84622 CCA94574 EAW88805 EAW88806 P19438 A21522 CAA01558 AK056611 BAG51763 AK130807 AK291088 BAF83777 AK298729 BAG60879 AK304517 BAG65321 AK308061 AK315509 BAG37891 AY182755 AAO23979 BC010140 AAH10140 BF528949 DA664652 EU176385 ABW03836 EU176726 ABW03527 EU927389 ACH57451 JN172914 AEO89726 M33294 AAA03210 M58286 AAA36753 M60275 AAA36756 M63121 AAA36754 NM_001065 NP_001056
Function	Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate- specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:22801493}; Single-pass type I membrane protein {ECO:0000269|PubMed:22801493}. Golgi apparatus membrane {ECO:0000269|PubMed:22801493}; Single- pass type I membrane protein {ECO:0000269|PubMed:22801493}. Secreted {ECO:0000269|PubMed:22801493}. Note=A secreted form is produced through proteolytic processing.
Top Pathways	Sphingolipid signaling pathway, Herpes simplex infection, TNF signaling pathway, Non-alcoholic fatty liver disease (NAFLD), Tuberculosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human TNF Receptor I protein fragment - ab157278 from Abcam Category Protein Prices $465.00 Sizes 50 µg Source HEK 293 cells Species Human

Active human TNF Receptor I protein fragment - ab174046 from Abcam Category Protein Prices $357.00 Sizes 100 µg Source HEK 293 cells Species Human

TNF Receptor I protein (Fc Chimera Active) - ab83577 from Abcam Category Protein Prices $315.00 Sizes 20 µg Source HEK 293 cells Species Human

Active human TNFRSF1A protein fragment - ab109144 from Abcam Category Protein Prices $410.00 Sizes 50 µg Source HEK 293 cells Species Human

Active Soluble TNF Receptor I full length protein - ab9980 from Abcam Category Protein Prices $257.00 Sizes 20 µg Source E. coli

Human TNF Receptor I full length protein - ab55573 from Abcam Category Protein Source E. coli Species Human

Human TNF Receptor I peptide - ab64288 from Abcam Category Peptide

Human TNF Receptor I protein fragment - ab134554 from Abcam Category Protein Source E. coli Species Human

Human TNF Receptor I protein fragment - ab51945 from Abcam Category Protein Source E. coli Species Human

Human TNFRSF1A protein fragment - ab111455 from Abcam Category Protein Source E. coli Species Human

Mouse TNFRSF1A protein fragment - ab185837 from Abcam Category Protein Source E. coli Species Mouse

Soluble TNF Receptor I peptide (2-13) - ab45654 from Abcam Category Peptide Species Human

TNFRSF1A / TNFR1 Antibody Blocking Peptide - LS-E790 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TNFRSF1A / TNFR1 Antibody Blocking Peptide - LS-E10620 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TNFRSF1A / TNFR1 Antibody Blocking Peptide - LS-E27845 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TNFRSF1A / TNFR1 Antibody Blocking Peptide - LS-E7326 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human TNF RI/TNFRSF1A Protein - NBP2-35274 from Novus Biologicals Category Protein Prices $69.00, $169.00, $2,669.00 Sizes 5 µg, 20 µg, 1 mg Source E. coli Species Human

TNF RI/TNFRSF1A Partial Recombinant Protein - H00007132-Q02 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

TNF RI/TNFRSF1A Recombinant Protein - H00007132-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Species Human

TNF RI/TNFRSF1A Partial Recombinant Protein - H00007132-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human TNF RI/TNFRSF1A Protein - NBP2-22906 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E.coli Species Human

TNF RI/TNFRSF1A Recombinant Protein - P4575 from Novus Biologicals Category Protein Prices $549.00 Sizes 20 µg Species Human

Recombinant Human TNF RI/TNFRSF1A Protein - NBP1-99318 from Novus Biologicals Category Protein Prices $185.00 Sizes 20 µg Source E. coli Species Human

TNF RI/TNFRSF1A Peptide - P1430 from Novus Biologicals Category Peptide Species Human

TNFR-S274-Antibody-Blocking-peptide - BP11142a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

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