TNFRSF1A

Gene Symbol	TNFRSF1A
Entrez Gene	7132
Alt Symbol	CD120a, FPF, MS5, TBP1, TNF-R, TNF-R-I, TNF-R55, TNFAR, TNFR1, TNFR1-d2, TNFR55, TNFR60, p55, p55-R, p60
Species	Human
Gene Type	protein-coding
Description	tumor necrosis factor receptor superfamily, member 1A
Other Description	TNF-R1|TNF-RI|TNFR-I|tumor necrosis factor binding protein 1|tumor necrosis factor receptor 1A isoform beta|tumor necrosis factor receptor superfamily member 1A|tumor necrosis factor receptor type 1|tumor necrosis factor-alpha receptor
Swissprots	D3DUR1 B4DQB7 B4E309 P19438 B2RDE4 B3KPQ1 B5M0B5 Q9UCA4 A8K4X3
Accessions	AAA61201 AAM77802 CAI84622 CCA94574 EAW88805 EAW88806 P19438 A21522 CAA01558 AK056611 BAG51763 AK130807 AK291088 BAF83777 AK298729 BAG60879 AK304517 BAG65321 AK308061 AK315509 BAG37891 AY182755 AAO23979 BC010140 AAH10140 BF528949 DA664652 EU176385 ABW03836 EU176726 ABW03527 EU927389 ACH57451 JN172914 AEO89726 M33294 AAA03210 M58286 AAA36753 M60275 AAA36756 M63121 AAA36754 NM_001065 NP_001056
Function	Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate- specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:22801493}; Single-pass type I membrane protein {ECO:0000269|PubMed:22801493}. Golgi apparatus membrane {ECO:0000269|PubMed:22801493}; Single- pass type I membrane protein {ECO:0000269|PubMed:22801493}. Secreted {ECO:0000269|PubMed:22801493}. Note=A secreted form is produced through proteolytic processing.
Top Pathways	Sphingolipid signaling pathway, Herpes simplex infection, TNF signaling pathway, Non-alcoholic fatty liver disease (NAFLD), Tuberculosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

TNFRSF1A overexpression lysate - LY400435 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

TNFRSF1A 293 Cell Lysate - 400451 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg Disease Tumor

TNF RI/TNFRSF1A Overexpression Lysate (Native) - NBL1-17154 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

TNFRSF1A Over-expression Lysate Product - GWB-997756 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Human TNFR1 / CD120a / TNFRSF1A HEK293 Cell Lysate (WB positive control) - 10872-H08HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human TNFR1 / CD120a / TNFRSF1A HEK293 Cell Lysate (WB positive control) - 10872-H03HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human TNFRSF1A Human Cells Transfected Lysate (positive control) (denatured) - orb173436 from Biorbyt Category Cell Lysate Prices $425.00 Sizes 300 μg Species Human

Human TNFRSF1A Human Cells Transfected Lysate (positive control) (denatured) - orb173097 from Biorbyt Category Cell Lysate Prices $425.00 Sizes 300 μg Species Human

Panoply™ Human TNFRSF1A Knockdown Stable Cell Line - CSC-DC016363 from Creative biogene Category Cell Line Species Human

Human TNFRSF1A Knockout Cell Line-HeLa - CSC-RT1286 from Creative biogene Category Cell Line Species Human

TNFRSF1A KO Cell Lysate-HeLa - CLKO-1139 from Creative biogene Category Cell Lysate

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