IL36B

Gene Symbol IL36B
Entrez Gene 27177
Alt Symbol FIL1, FIL1-(ETA), FIL1H, FILI-(ETA), IL-1F8, IL-1H2, IL1-ETA, IL1F8, IL1H2
Species Human
Gene Type protein-coding
Description interleukin 36, beta
Other Description FIL1 eta|IL-1 eta|IL-1F8 (FIL1-eta)|IL1F8 (Canonical product IL-1F8a)|Interleukin-1 Superfamily e|family of interleukin 1-eta|interleukin 1 family, member 8 (eta)|interleukin 1, eta|interleukin-1 eta|interleukin-1 family member 8|interleukin-1 homolog 2|interleukin-36 beta
Swissprots Q7RTZ7 Q9UHA5 Q3MIH0 Q53SR6 Q9NZH7
Accessions AAY14989 ABA60896 CAD29876 EAW73615 EAW73616 Q9NZH7 AF200494 AAF69250 AF201833 AAF25213 BC101831 AAI01832 BC101833 AAI01834 CA441070 XM_011510962 XP_011509264 NM_014438 NP_055253 NM_173178 NP_775270
Function Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes. Induces expression of a number of antimicrobial peptides including beta-defensins 4 and 103 as well as a number of matrix metalloproteases. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, C
Subcellular Location Secreted {ECO:0000269|PubMed:16646978}.
Tissue Specificity Expression at low levels in tonsil, bone marrow, heart, placenta, lung, testis and colon but not in any hematopoietic cell lines. Not detected in adipose tissue. Expressed at higher levels in psoriatic plaques than in symptomless psoriatic skin or healthy control skin. Increased levels are not detected in inflamed joint tissue. {ECO:0000269|PubMed:20300079, ECO:0000269|PubMed:21242515}.

IL-1F8 (N-16) - sc-168156 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-IL36 beta antibody - ab116280 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-IL36 beta antibody (ab116280) at 1 µg/ml (Milk blocking 3%)Lane 1 : Tonsil (Human) Tissue LysateLane 2 : Tonsil (Human) Tissue Lysate with Immunising peptide at 1 µg/mlLysates/proteins at 25 µg per lane.SecondaryDonkey Anti-Rabbit IgG H&L preadsorbed (ab97081) at 1/10000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-IL36 beta antibody - ab69411 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-IL36 beta antibody (ab69411) at 1/500 dilutionLane 1 : IL1F8 transfected 293T lysateLane 2 : Non-transfected 293T lysateLysates/proteins at 25 µg per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution

Anti-IL36 beta antibody [MM0387-2Q27] - ab90933 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone MM0387-2Q27

Anti-IL36 beta antibody - C-terminal - ab180890 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-IL36 beta antibody - C-terminal (ab180890) at 1 µg/mlLane 1 : A549 cell lysateLane 2 : A549 cell lysate with blocking peptideLysates/proteins at 15 µg per lane.

Anti-IL36 beta antibody - N-terminal - ab175859 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-IL36 beta antibody - N-terminal (ab175859) at 1/1000 dilutionLane 1 : Non transfected 293 cell lysateLane 2 : 293 cell lysate transiently transfected with the IL36 beta geneLysates/proteins at 2 µg per lane.

Anti-IL36B Antibody (N-Terminus, AP) - LS-C244758 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IL36B Antibody (N-Terminus, Biotin) - LS-C244760 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IL36B Antibody (N-Terminus, APC) - LS-C244759 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IL36B Antibody (N-Terminus, FITC) - LS-C244761 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IL36B Antibody - LS-C308459 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-IL36B Antibody (N-Terminus, PE) - LS-C244762 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IL36B Antibody (N-Terminus, Azide-free, HRP) - LS-C247649 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IL36B Antibody (N-Terminus) - LS-C330475 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-IL36B Antibody (clone 1E4) - LS-C139455 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1E4
Western blot of IL1F8 expression in transfected 293T cell line by IL1F8 monoclonal antibody (M01), clone 1E4.

Anti-IL36B Antibody (aa1-30) - LS-C165188 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of IL1F8 (arrow) using rabbit polyclonal IL1F8 Antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the IL1F8 gene (Lane 2).

Anti-IL36B Antibody (C-Terminus) IHC-plus™ - LS-B10136 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-IL36B antibody IHC staining of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B10136 concentration 10 ug/ml.

IL-36 beta/IL-1F8 Antibody - AF1099 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Neutralization IL-36 beta/IL-1F8 Antibody

IL1F8 Antibody - NBP1-83892 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: IL1F8 Antibody [NBP1-83892] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Negative control (vector only transfected HEK293T lysate). Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).

IL1F8 Antibody - H00027177-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: IL1F8 Antibody [H00027177-B01P] - Analysis of IL1F8 expression in transfected 293T cell line by IL1F8 polyclonal antibody. Lane1:IL1F8 transfected lysate(17.27 KDa). Lane2:Non-transfected lysate.

IL1F8 Antibody (MM0387-2Q27) - NBP2-11687 from Novus Biologicals

Prices $349.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone MM0387-2Q27

IL1F8 Antibody (1E4) - H00027177-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1E4

IL-36 beta/IL-1F8 Antibody [Biotin] - BAF1099 from Novus Biologicals

Prices $420.00
Sizes 50 µg
Host Goat
Clonality Polyclonal

IL-36 beta/IL-1F8 Antibody - NBP2-41239 from Novus Biologicals

Prices $369.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: IL-36 beta/IL-1F8 Antibody [NBP2-41239] - Western blot analysis of IL-36B in A549 cell lysate with IL-36B antibody at 1 ug/ml in (A) the absence and (B) the presence of blocking peptide.

Monoclonal Anti-IL1F8 antibody produced in mouse - SAB1403196 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1E4
<B>Immunoblotting</B><BR/>Monoclonal Anti-IL1F8: <B>Cat. No. SAB1403196</B>: Antibody concentration: 0.1-5 μg/mL. Specific band of ~17.7 kDa using IL1F8 transfected 293T lysate.<BR/><B>Lanes</B><BR/>1. Transfected 293T lysate.<BR/>2. Non-transfected 293T lysate.
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