IL36B

Gene Symbol	IL36B
Entrez Gene	27177
Alt Symbol	FIL1, FIL1-(ETA), FIL1H, FILI-(ETA), IL-1F8, IL-1H2, IL1-ETA, IL1F8, IL1H2
Species	Human
Gene Type	protein-coding
Description	interleukin 36, beta
Other Description	FIL1 eta|IL-1 eta|IL-1F8 (FIL1-eta)|IL1F8 (Canonical product IL-1F8a)|Interleukin-1 Superfamily e|family of interleukin 1-eta|interleukin 1 family, member 8 (eta)|interleukin 1, eta|interleukin-1 eta|interleukin-1 family member 8|interleukin-1 homolog 2|interleukin-36 beta
Swissprots	Q7RTZ7 Q9UHA5 Q3MIH0 Q53SR6 Q9NZH7
Accessions	AAY14989 ABA60896 CAD29876 EAW73615 EAW73616 Q9NZH7 AF200494 AAF69250 AF201833 AAF25213 BC101831 AAI01832 BC101833 AAI01834 CA441070 XM_011510962 XP_011509264 NM_014438 NP_055253 NM_173178 NP_775270
Function	Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes. Induces expression of a number of antimicrobial peptides including beta-defensins 4 and 103 as well as a number of matrix metalloproteases. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, C
Subcellular Location	Secreted {ECO:0000269|PubMed:16646978}.
Tissue Specificity	Expression at low levels in tonsil, bone marrow, heart, placenta, lung, testis and colon but not in any hematopoietic cell lines. Not detected in adipose tissue. Expressed at higher levels in psoriatic plaques than in symptomless psoriatic skin or healthy control skin. Increased levels are not detected in inflamed joint tissue. {ECO:0000269|PubMed:20300079, ECO:0000269|PubMed:21242515}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

IL1F8-Over-expression-Lysate - LY10525a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

IL1F8 293T Cell Transient Overexpression Lysate(Denatured) - H00027177-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

IL36B overexpression lysate - LY406635 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

IL1F8 293 Cell Lysate - 403990 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

IL1F8 Overexpression Lysate (Denatured) - H00027177-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

IL1F8 Overexpression Lysate (Native) - NBL1-11926 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

IL1F8 Over-expression Lysate Product - GWB-E4642A from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Panoply™ Human IL36B Knockdown Stable Cell Line - CSC-DC007600 from Creative biogene Category Cell Line Species Human

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