IL36B

Gene Symbol	IL36B
Entrez Gene	27177
Alt Symbol	FIL1, FIL1-(ETA), FIL1H, FILI-(ETA), IL-1F8, IL-1H2, IL1-ETA, IL1F8, IL1H2
Species	Human
Gene Type	protein-coding
Description	interleukin 36, beta
Other Description	FIL1 eta|IL-1 eta|IL-1F8 (FIL1-eta)|IL1F8 (Canonical product IL-1F8a)|Interleukin-1 Superfamily e|family of interleukin 1-eta|interleukin 1 family, member 8 (eta)|interleukin 1, eta|interleukin-1 eta|interleukin-1 family member 8|interleukin-1 homolog 2|interleukin-36 beta
Swissprots	Q7RTZ7 Q9UHA5 Q3MIH0 Q53SR6 Q9NZH7
Accessions	AAY14989 ABA60896 CAD29876 EAW73615 EAW73616 Q9NZH7 AF200494 AAF69250 AF201833 AAF25213 BC101831 AAI01832 BC101833 AAI01834 CA441070 XM_011510962 XP_011509264 NM_014438 NP_055253 NM_173178 NP_775270
Function	Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes. Induces expression of a number of antimicrobial peptides including beta-defensins 4 and 103 as well as a number of matrix metalloproteases. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, C
Subcellular Location	Secreted {ECO:0000269|PubMed:16646978}.
Tissue Specificity	Expression at low levels in tonsil, bone marrow, heart, placenta, lung, testis and colon but not in any hematopoietic cell lines. Not detected in adipose tissue. Expressed at higher levels in psoriatic plaques than in symptomless psoriatic skin or healthy control skin. Increased levels are not detected in inflamed joint tissue. {ECO:0000269|PubMed:20300079, ECO:0000269|PubMed:21242515}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human IL36 beta protein fragment - ab138901 from Abcam Category Protein Prices $110.00, $192.00 Sizes 2 µg, 10 µg Source E. coli Species Human

Human IL36 beta peptide - ab173369 from Abcam Category Peptide

IL36B Antibody Blocking Peptide - LS-E9873 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human IL-36 beta/IL-1F8 Protein - NBP2-34882 from Novus Biologicals Category Protein Prices $69.00, $169.00, $4,629.00 Sizes 2 µg, 10 µg, 1 mg Source E. coli Species Human

Recombinant Human IL-36 beta/IL-1F8 Protein - NBP2-34887 from Novus Biologicals Category Protein Prices $69.00, $169.00, $4,629.00 Sizes 2 µg, 10 µg, 1 mg Source E. coli Species Human

Recombinant Human IL1F8 Protein - H00027177-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

IL1F8-Antibody-N-term-Blocking-Peptide - BP8956a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

IL1F8 recombinant protein - GTX53810 from GeneTex Category Protein Prices $199.00 Sizes 10 μg Source E. Coli

Recombinant Human IL-36 beta/IL-1F8 (aa 5-157) - 6834-IL-010 from R&D Systems Category Protein Source E. coli-derived, Arg5-Glu157

Recombinant Human IL-36 beta/IL-1F8 - 1099-IL-025 from R&D Systems Category Protein Source E. coli-derived, Met1-Glu157

Recombinant Human IL-36 beta/IL-1F8, CF - 1099-IL-025/CF from R&D Systems Category Protein Source E. coli-derived, Met1-Glu157

Human IL36B protein - orb168602 from Biorbyt Category Protein Prices $187.00, $323.00, $5,372.00 Sizes 2 μg, 10 μg, 1 mg Source E. coli

Human IL1F8 (His Tag) protein - orb179528 from Biorbyt Category Protein Prices $357.00, $510.00 Sizes 10 μg, 20 μg Source E. coli Species Human

Mouse IL36B protein - orb168603 from Biorbyt Category Protein Prices $230.00, $442.00 Sizes 2 μg, 10 μg Source E. coli Species Mouse

Human IL1F8 protein (Native) - orb139149 from Biorbyt Category Protein Prices $323.00, $612.00 Sizes 20 μg, 50 μg Source E. coli Species Human

IL1F8 / IL1H2 - AR31087PU-N from Acris Antibodies Category Protein Prices $235.00 Sizes 10 µg Source E. coli Species Human

IL1F8 / IL1H2 - AR31087PU-S from Acris Antibodies Category Protein Prices $135.00 Sizes 2 µg Source E. coli Species Human

IL1F8 / IL1H2 - H00027177-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

IL1F8 / IL1H2 - H00027177-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

IL1F8 / IL1H2 - P6098 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

IL-36 beta (IL-1F8), Human, Recombinant - 28-10036B from ARP American Research Products Category Protein Prices $99.00, $104.00, $199.00 Sizes 2 µg, 1 mg, 10 µg Source E. Coli Species Human

IL-36B Peptide - 7507P from ProSci Category Peptide Species Human

IL-36beta Recombinant Protein - 40-602 from ProSci Category Protein Prices $150.00, $250.00 Sizes 2 µg, 10 µg Source E. coli Species Human

IL1F8 fusion protein - Ag12675 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

IL1F8 fusion protein - Ag12692 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

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