| Gene Symbol | IL36B |
|---|---|
| Entrez Gene | 27177 |
| Alt Symbol | FIL1, FIL1-(ETA), FIL1H, FILI-(ETA), IL-1F8, IL-1H2, IL1-ETA, IL1F8, IL1H2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | interleukin 36, beta |
| Other Description | FIL1 eta|IL-1 eta|IL-1F8 (FIL1-eta)|IL1F8 (Canonical product IL-1F8a)|Interleukin-1 Superfamily e|family of interleukin 1-eta|interleukin 1 family, member 8 (eta)|interleukin 1, eta|interleukin-1 eta|interleukin-1 family member 8|interleukin-1 homolog 2|interleukin-36 beta |
| Swissprots | Q7RTZ7 Q9UHA5 Q3MIH0 Q53SR6 Q9NZH7 |
| Accessions | AAY14989 ABA60896 CAD29876 EAW73615 EAW73616 Q9NZH7 AF200494 AAF69250 AF201833 AAF25213 BC101831 AAI01832 BC101833 AAI01834 CA441070 XM_011510962 XP_011509264 NM_014438 NP_055253 NM_173178 NP_775270 |
| Function | Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes. Induces expression of a number of antimicrobial peptides including beta-defensins 4 and 103 as well as a number of matrix metalloproteases. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, C |
| Subcellular Location | Secreted {ECO:0000269|PubMed:16646978}. |
| Tissue Specificity | Expression at low levels in tonsil, bone marrow, heart, placenta, lung, testis and colon but not in any hematopoietic cell lines. Not detected in adipose tissue. Expressed at higher levels in psoriatic plaques than in symptomless psoriatic skin or healthy control skin. Increased levels are not detected in inflamed joint tissue. {ECO:0000269|PubMed:20300079, ECO:0000269|PubMed:21242515}. |