IL36B

Gene Symbol IL36B
Entrez Gene 27177
Alt Symbol FIL1, FIL1-(ETA), FIL1H, FILI-(ETA), IL-1F8, IL-1H2, IL1-ETA, IL1F8, IL1H2
Species Human
Gene Type protein-coding
Description interleukin 36, beta
Other Description FIL1 eta|IL-1 eta|IL-1F8 (FIL1-eta)|IL1F8 (Canonical product IL-1F8a)|Interleukin-1 Superfamily e|family of interleukin 1-eta|interleukin 1 family, member 8 (eta)|interleukin 1, eta|interleukin-1 eta|interleukin-1 family member 8|interleukin-1 homolog 2|interleukin-36 beta
Swissprots Q7RTZ7 Q9UHA5 Q3MIH0 Q53SR6 Q9NZH7
Accessions AAY14989 ABA60896 CAD29876 EAW73615 EAW73616 Q9NZH7 AF200494 AAF69250 AF201833 AAF25213 BC101831 AAI01832 BC101833 AAI01834 CA441070 XM_011510962 XP_011509264 NM_014438 NP_055253 NM_173178 NP_775270
Function Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes. Induces expression of a number of antimicrobial peptides including beta-defensins 4 and 103 as well as a number of matrix metalloproteases. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, C
Subcellular Location Secreted {ECO:0000269|PubMed:16646978}.
Tissue Specificity Expression at low levels in tonsil, bone marrow, heart, placenta, lung, testis and colon but not in any hematopoietic cell lines. Not detected in adipose tissue. Expressed at higher levels in psoriatic plaques than in symptomless psoriatic skin or healthy control skin. Increased levels are not detected in inflamed joint tissue. {ECO:0000269|PubMed:20300079, ECO:0000269|PubMed:21242515}.

Human IL36B ELISA Kit (Sandwich ELISA) - LS-F7979 from LifeSpan Bioscience

Category ELISA Kit
Prices $720.00
Sizes 1 plate
Sensitivity 2.7 pg/ml
Range 7.81-500 pg/ml

Human IL36B ELISA Kit (Sandwich ELISA) - LS-F11792 from LifeSpan Bioscience

Category ELISA Kit
Prices $600.00
Sizes 1 plate
Sensitivity 31.2
Range 7.81-500 pg/ml

Interleukin 1 Eta (IL1h), Human, ELISA Kit - SED134Hu from ARP American Research Products

Category ELISA Kit
Prices $720.00
Sizes 96 t
Sensitivity 6.6pg/mL
Range 15.6-1,000pg/mL

Interleukin-36 beta, Human, ELISA Kit - E01I0119 from ARP American Research Products

Category ELISA Kit
Prices $535.00, $735.00
Sizes 48 t, 96 t

Interleukin-36 beta, IL36B, Human, ELISA Kit - E2013h from ARP American Research Products

Category ELISA Kit
Prices $596.00
Sizes 96 t
Range 78-5000 pg/mL

Interleukin 1 Eta, FIL1h, Mouse, ELISA Kit - E-EL-M0719 from ARP American Research Products

Category ELISA Kit
Prices $585.00
Sizes 96 t

Interleukin 1 Eta, FIL1h, Rat, ELISA Kit - E-EL-R0551 from ARP American Research Products

Category ELISA Kit
Prices $585.00
Sizes 96 t

Interleukin 1 Eta (IL1h), Human, CLIA Kit - SCD134Hu from ARP American Research Products

Category CLIA Kit
Prices $840.00
Sizes 96 t
Sensitivity 6.7pg/mL
Range 15.6-1,000pg/mL

Anserine FIL1h ELISA Kit - AF0099 from NeoScientific

Category ELISA Kit
Prices $495.00
Sizes 96 t

Interleukin 36 beta, ELISA Kit - MBS746285 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 1.0 pg/mL.

Interleukin 1 Eta, ELISA Kit - MBS039189 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Interleukin 1 Eta, ELISA Kit - MBS738838 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 1.0 pg/mL.

Interleukin 1 Eta, ELISA Kit - MBS009752 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Interleukin 1 Eta, ELISA Kit - MBS043302 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Interleukin 1 Eta, ELISA Kit - MBS009519 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Interleukin 1 Eta, ELISA Kit - MBS721457 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,850.00, $5,340.00
Sizes 48 -strip-wells- (Competitive), 96 -strip-wells- (Competitive), 5x96-strip-wells- (Competitive), 10x96-strip-wells- (Competitive)
Sensitivity 1.0 pg/mL.

Interleukin 1 Eta, ELISA Kit - MBS099384 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Interleukin 1 Eta, ELISA Kit - MBS031049 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Interleukin 1 Eta, ELISA Kit - MBS727631 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 1.0 pg/mL.

Interleukin 1 Eta, ELISA Kit - MBS720470 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,850.00, $5,340.00
Sizes 48 -strip-wells- (Competitive), 96 -strip-wells- (Competitive), 5x96-strip-wells- (Competitive), 10x96-strip-wells- (Competitive)
Sensitivity 1.0 pg/mL.

Interleukin 1 Eta, ELISA Kit - MBS725849 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,850.00, $5,340.00
Sizes 48 -strip-wells- (Competitive), 96 -strip-wells- (Competitive), 5x96-strip-wells- (Competitive), 10x96-strip-wells- (Competitive)
Sensitivity 1.0 pg/mL.

Interleukin 1 Eta, ELISA Kit - MBS044895 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Interleukin 1 Eta, ELISA Kit - MBS070260 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Interleukin 1 Eta, ELISA Kit - MBS044409 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
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