| Gene Symbol | IL36B |
|---|---|
| Entrez Gene | 27177 |
| Alt Symbol | FIL1, FIL1-(ETA), FIL1H, FILI-(ETA), IL-1F8, IL-1H2, IL1-ETA, IL1F8, IL1H2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | interleukin 36, beta |
| Other Description | FIL1 eta|IL-1 eta|IL-1F8 (FIL1-eta)|IL1F8 (Canonical product IL-1F8a)|Interleukin-1 Superfamily e|family of interleukin 1-eta|interleukin 1 family, member 8 (eta)|interleukin 1, eta|interleukin-1 eta|interleukin-1 family member 8|interleukin-1 homolog 2|interleukin-36 beta |
| Swissprots | Q7RTZ7 Q9UHA5 Q3MIH0 Q53SR6 Q9NZH7 |
| Accessions | AAY14989 ABA60896 CAD29876 EAW73615 EAW73616 Q9NZH7 AF200494 AAF69250 AF201833 AAF25213 BC101831 AAI01832 BC101833 AAI01834 CA441070 XM_011510962 XP_011509264 NM_014438 NP_055253 NM_173178 NP_775270 |
| Function | Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes. Induces expression of a number of antimicrobial peptides including beta-defensins 4 and 103 as well as a number of matrix metalloproteases. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, C |
| Subcellular Location | Secreted {ECO:0000269|PubMed:16646978}. |
| Tissue Specificity | Expression at low levels in tonsil, bone marrow, heart, placenta, lung, testis and colon but not in any hematopoietic cell lines. Not detected in adipose tissue. Expressed at higher levels in psoriatic plaques than in symptomless psoriatic skin or healthy control skin. Increased levels are not detected in inflamed joint tissue. {ECO:0000269|PubMed:20300079, ECO:0000269|PubMed:21242515}. |
IL-1F8 CRISPR/Cas9 KO Plasmid (h) - sc-411976 from Santa Cruz Biotechnology
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IL-1F8 HDR Plasmid (h) - sc-411976-HDR from Santa Cruz Biotechnology
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IL-1F8 Double Nickase Plasmid (h) - sc-411976-NIC from Santa Cruz Biotechnology
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IL-1F8 Double Nickase Plasmid (h2) - sc-411976-NIC-2 from Santa Cruz Biotechnology
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IL-1F8 CRISPR Activation Plasmid (h) - sc-411976-ACT from Santa Cruz Biotechnology
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IL-1F8 CRISPR Activation Plasmid (h2) - sc-411976-ACT-2 from Santa Cruz Biotechnology
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IL-1F8 Lentiviral Activation Particles (h) - sc-411976-LAC from Santa Cruz Biotechnology
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IL-1F8 Lentiviral Activation Particles (h2) - sc-411976-LAC-2 from Santa Cruz Biotechnology
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IL-1F8 siRNA (h) - sc-72175 from Santa Cruz Biotechnology
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IL-1F8 shRNA Plasmid (h) - sc-72175-SH from Santa Cruz Biotechnology
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IL-1F8 shRNA (h) Lentiviral Particles - sc-72175-V from Santa Cruz Biotechnology
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IL-1F8 siRNA (h) - sc-94991 from Santa Cruz Biotechnology
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IL-1F8 shRNA Plasmid (h) - sc-94991-SH from Santa Cruz Biotechnology
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IL-1F8 shRNA (h) Lentiviral Particles - sc-94991-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN10594 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10594 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04777 from Sigma-Aldrich
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IL36B siRNA (Human) - CRH9009 from Cohesion Biosciences
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IL36B - MBS8236996 from MyBioSource
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shRNA set against Human IL36B (NM_173178.1) - SHH318953 from Creative biogene
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shRNA set against Human IL1F8(NM_173178.1) - SHL172404 from Creative biogene
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shRNA set against Human IL1F8(NM_014438.3) - SHL172470 from Creative biogene
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Human IL36B siRNA - orb269511 from Biorbyt
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IL36B shRNA Plasmid (Human) - CHH9009 from Cohesion Biosciences
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IL36B miRNA 3'UTR clone - MiUTR1H-04894 from Creative biogene
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