SNAI1

Gene Symbol	SNAI1
Entrez Gene	6615
Alt Symbol	SLUGH2, SNA, SNAH, SNAIL, SNAIL1, dJ710H13.1
Species	Human
Gene Type	protein-coding
Description	snail family zinc finger 1
Other Description	protein sna|protein snail homolog 1|snail 1 homolog|snail 1 zinc finger protein|snail 1, zinc finger protein|snail homolog 1|zinc finger protein SNAI1
Swissprots	Q9P113 Q9UHH7 B2R842 O95863 Q9UBP7
Accessions	AAD52986 AAD52996 CAB52414 CBX55848 EAW75640 O95863 AF125377 AAD17332 AF131208 AAF32527 AK313228 BAG36039 BC012910 AAH12910 BI822180 DA972913 DQ891599 ABM82525 DQ894793 ABM85719 NM_005985 NP_005976
Function	Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up- regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself. {ECO:0000269|PubMed:10655587, ECO:0000269|PubMed:15647282, ECO:0000269|PubMed:16096638, ECO:0000269|PubMed:20121949, ECO:0000269|PubMed:20562920, ECO:0000269|PubMed:21952048}.
Subcellular Location	Nucleus. Cytoplasm. Note=Once phosphorylated (probably on Ser-107, Ser-111, Ser-115 and Ser-119) it is exported from the nucleus to the cytoplasm where subsequent phosphorylation of the destruction motif and ubiquitination involving BTRC occurs.
Tissue Specificity	Expressed in a variety of tissues with the highest expression in kidney. Expressed in mesenchymal and epithelial cell lines. {ECO:0000269|PubMed:10655587}.
Top Pathways	Adherens junction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SNAI1-Over-expression-Lysate - LY13189a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

SNAI1-Over-expression-Lysate - LY10409a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

SNAI1 293T Cell Transient Overexpression Lysate(Denatured) - H00006615-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

SNAI1 293T Cell Transient Overexpression Lysate(Denatured) - H00006615-T02 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

SNAI1 overexpression lysate - LY401811 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

SNAI1 293 Cell Lysate - 401615 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg Species Drosophila

Snail Overexpression Lysate (Denatured) - H00006615-T02 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl Species Human

Snail Overexpression Lysate (Denatured) - H00006615-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Snail Overexpression Lysate (Native) - NBL1-16265 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

SNAI 1 (h): 293T Lysate - sc-113766 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

SNAI1 Over-expression Lysate Product - GWB-1B2BC8 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Snail Overexpression Lysate (Denatured) - H00006615-T03 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

Panoply™ Human SNAI1 Knockdown Stable Cell Line - CSC-DC014790 from Creative biogene Category Cell Line Species Human

Search more