SNAI1

Gene Symbol	SNAI1
Entrez Gene	6615
Alt Symbol	SLUGH2, SNA, SNAH, SNAIL, SNAIL1, dJ710H13.1
Species	Human
Gene Type	protein-coding
Description	snail family zinc finger 1
Other Description	protein sna|protein snail homolog 1|snail 1 homolog|snail 1 zinc finger protein|snail 1, zinc finger protein|snail homolog 1|zinc finger protein SNAI1
Swissprots	Q9P113 Q9UHH7 B2R842 O95863 Q9UBP7
Accessions	AAD52986 AAD52996 CAB52414 CBX55848 EAW75640 O95863 AF125377 AAD17332 AF131208 AAF32527 AK313228 BAG36039 BC012910 AAH12910 BI822180 DA972913 DQ891599 ABM82525 DQ894793 ABM85719 NM_005985 NP_005976
Function	Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up- regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself. {ECO:0000269|PubMed:10655587, ECO:0000269|PubMed:15647282, ECO:0000269|PubMed:16096638, ECO:0000269|PubMed:20121949, ECO:0000269|PubMed:20562920, ECO:0000269|PubMed:21952048}.
Subcellular Location	Nucleus. Cytoplasm. Note=Once phosphorylated (probably on Ser-107, Ser-111, Ser-115 and Ser-119) it is exported from the nucleus to the cytoplasm where subsequent phosphorylation of the destruction motif and ubiquitination involving BTRC occurs.
Tissue Specificity	Expressed in a variety of tissues with the highest expression in kidney. Expressed in mesenchymal and epithelial cell lines. {ECO:0000269|PubMed:10655587}.
Top Pathways	Adherens junction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SNAIL full length protein - ab134870 from Abcam Category Protein Source E. coli Species Human

Human SNAIL full length protein - ab176060 from Abcam Category Protein Source E. coli Species Human

Human SNAIL peptide - ab19126 from Abcam Category Peptide

Human SNAIL protein fragment - ab114553 from Abcam Category Protein Source Wheat germ Species Human

SNAIL peptide - ab134217 from Abcam Category Peptide

SNAI1 / SNAIL-1 Antibody Blocking Peptide - LS-E6837 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SNAI1 / SNAIL-1 Antibody Blocking Peptide - LS-E6836 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SNAI1 / SNAIL-1 Antibody Blocking Peptide - LS-E6838 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SNAI1 / SNAIL-1 Antibody Blocking Peptide - LS-E6839 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SNAI1 / SNAIL-1 Antibody Blocking Peptide - LS-E11746 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SNAI1 / SNAIL-1 Antibody Blocking Peptide - LS-E26164 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Snail Partial Recombinant Protein - H00006615-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Snail Recombinant Protein - H00006615-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 10 ug 25 ug Species Human

Recombinant Human Snail Protein - NBP2-22814 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E.coli Species Human

SNAI1-Antibody-N-term-R8-Blocking-Peptide - BP2054e from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SNAI1-Antibody-N-term-Blocking-Peptide - BP2054d from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SNAI1-Antibody-N-term-R8-Blocking-peptide - BP2054b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SNAI1-Antibody-N-term-D24-Blocking-Peptide - BP2054a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SNAI1 blocking peptide - GTX89239-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Rat

SNAI1 Protein Lysate (APL10260) - APL10260 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

SNAI1 Blocking Peptide - 33R-6304 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SNAI1 protein (His tag) - 80R-3546 from Fitzgerald Category Protein Prices $275.00 Sizes 100 µg Source E.coli

SNAI1 Blocking Peptide - abx063280 from Abbexa Category Peptide Species Human, Mouse

SNAIL Peptide - AC21-0994-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

SNAI1 (1-264, His-tag) - AR51234PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

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