| Gene Symbol |
SNAI1
|
| Entrez Gene |
6615
|
| Alt Symbol |
SLUGH2, SNA, SNAH, SNAIL, SNAIL1, dJ710H13.1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
snail family zinc finger 1
|
| Other Description |
protein sna|protein snail homolog 1|snail 1 homolog|snail 1 zinc finger protein|snail 1, zinc finger protein|snail homolog 1|zinc finger protein SNAI1
|
| Swissprots |
Q9P113 Q9UHH7 B2R842 O95863 Q9UBP7
|
| Accessions |
AAD52986 AAD52996 CAB52414 CBX55848 EAW75640 O95863 AF125377 AAD17332 AF131208 AAF32527 AK313228 BAG36039 BC012910 AAH12910 BI822180 DA972913 DQ891599 ABM82525 DQ894793 ABM85719 NM_005985 NP_005976
|
| Function |
Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up- regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself. {ECO:0000269|PubMed:10655587, ECO:0000269|PubMed:15647282, ECO:0000269|PubMed:16096638, ECO:0000269|PubMed:20121949, ECO:0000269|PubMed:20562920, ECO:0000269|PubMed:21952048}.
|
| Subcellular Location |
Nucleus. Cytoplasm. Note=Once phosphorylated (probably on Ser-107, Ser-111, Ser-115 and Ser-119) it is exported from the nucleus to the cytoplasm where subsequent phosphorylation of the destruction motif and ubiquitination involving BTRC occurs.
|
| Tissue Specificity |
Expressed in a variety of tissues with the highest expression in kidney. Expressed in mesenchymal and epithelial cell lines. {ECO:0000269|PubMed:10655587}.
|
| Top Pathways |
Adherens junction
|