SNAI1
| Gene Symbol | SNAI1 |
|---|---|
| Entrez Gene | 6615 |
| Alt Symbol | SLUGH2, SNA, SNAH, SNAIL, SNAIL1, dJ710H13.1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | snail family zinc finger 1 |
| Other Description | protein sna|protein snail homolog 1|snail 1 homolog|snail 1 zinc finger protein|snail 1, zinc finger protein|snail homolog 1|zinc finger protein SNAI1 |
| Swissprots | Q9P113 Q9UHH7 B2R842 O95863 Q9UBP7 |
| Accessions | AAD52986 AAD52996 CAB52414 CBX55848 EAW75640 O95863 AF125377 AAD17332 AF131208 AAF32527 AK313228 BAG36039 BC012910 AAH12910 BI822180 DA972913 DQ891599 ABM82525 DQ894793 ABM85719 NM_005985 NP_005976 |
| Function | Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up- regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself. {ECO:0000269|PubMed:10655587, ECO:0000269|PubMed:15647282, ECO:0000269|PubMed:16096638, ECO:0000269|PubMed:20121949, ECO:0000269|PubMed:20562920, ECO:0000269|PubMed:21952048}. |
| Subcellular Location | Nucleus. Cytoplasm. Note=Once phosphorylated (probably on Ser-107, Ser-111, Ser-115 and Ser-119) it is exported from the nucleus to the cytoplasm where subsequent phosphorylation of the destruction motif and ubiquitination involving BTRC occurs. |
| Tissue Specificity | Expressed in a variety of tissues with the highest expression in kidney. Expressed in mesenchymal and epithelial cell lines. {ECO:0000269|PubMed:10655587}. |
| Top Pathways | Adherens junction |
SNAI 1 CRISPR/Cas9 KO Plasmid (h) - sc-400244 from Santa Cruz Biotechnology
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SNAI 1 HDR Plasmid (h) - sc-400244-HDR from Santa Cruz Biotechnology
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SNAI 1 Double Nickase Plasmid (h) - sc-400244-NIC from Santa Cruz Biotechnology
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SNAI 1 Double Nickase Plasmid (h2) - sc-400244-NIC-2 from Santa Cruz Biotechnology
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SNAI 1 CRISPR Activation Plasmid (h) - sc-400244-ACT from Santa Cruz Biotechnology
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SNAI 1 CRISPR Activation Plasmid (h2) - sc-400244-ACT-2 from Santa Cruz Biotechnology
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SNAI 1 Lentiviral Activation Particles (h) - sc-400244-LAC from Santa Cruz Biotechnology
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SNAI 1 Lentiviral Activation Particles (h2) - sc-400244-LAC-2 from Santa Cruz Biotechnology
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SNAI 1 siRNA (h) - sc-38398 from Santa Cruz Biotechnology
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SNAI 1 shRNA Plasmid (h) - sc-38398-SH from Santa Cruz Biotechnology
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SNAI 1 shRNA (h) Lentiviral Particles - sc-38398-V from Santa Cruz Biotechnology
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Snail RNAi - H00006615-R01 from Novus Biologicals
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MISSION® esiRNA - EHU030431 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1334 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1334 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR12333 from Sigma-Aldrich
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SNAI1 siRNA (Human) - CRH4498 from Cohesion Biosciences
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SNAI1 - MBS8220157 from MyBioSource
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Human SNAI1 siRNA - orb265000 from Biorbyt
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SNAI1 shRNA Plasmid (Human) - CHH4498 from Cohesion Biosciences
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SNAI1 miRNA 3'UTR clone - MiUTR3H-06668 from Creative biogene
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