SOCS5

Gene Symbol SOCS5
Entrez Gene 9655
Alt Symbol CIS6, CISH6, Cish5, SOCS-5
Species Human
Gene Type protein-coding
Description suppressor of cytokine signaling 5
Other Description CIS-6|cytokine-inducible SH2 protein 6|cytokine-inducible SH2-containing protein 5
Swissprots O75159 Q8IYZ4 Q53SD4
Accessions AAY24289 EAX00235 EAX00236 EAX00237 O75159 AB014571 BAA31646 AF073958 AAD40484 AI433294 AK290194 BAF82883 AK296796 BAG59372 AL136896 CAB66830 BC032862 AAH32862 DQ891213 ABM82139 DQ894396 ABM85322 NM_014011 NP_054730 NM_144949 NP_659198
Function SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling. {ECO:0000269|PubMed:15590694}.
Top Pathways Jak-STAT signaling pathway, Prolactin signaling pathway

SOCS-5 (L-20) - sc-8286 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SOCS-5 (L-20): sc-8286. Western blot analysis of SOCS-5 expression in BJAB (A) and Jurkat (B) whole cell lysates.

SOCS-5 (M-19) - sc-8287 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SOCS-5 (M-19): sc-8287. Western blot analysis of SOCS-5 expression in rat spleen (A) and mouse spleen (B) tissue extracts.

SOCS-5 (M-300) - sc-5607 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
SOCS-5 (M-300): sc-5607. Immunofluorescence staining of methanol-fixed RAW 264.7 cells showing cytoplasmic localization.

SOCS-5 (31-L) - sc-100858 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
SOCS-5 (31-L): sc-100858. Western blot analysis of SOCS-5 expression in Hep G2 whole cell lysate.

Anti-SOCS5 antibody - ab3695 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ab3695 staining formalin-fixed, paraffin embeded tissue section of cardiac myocytes within human heart. The primary antibody was diluted 10 μg/ml and it was detected by ABC kit. Nuclears are counterstained with hematoxylin purple.

Anti-SOCS5 antibody - ab125265 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-SOCS5 antibody (ab125265) at 1/500 dilution + Mouse liver tissue lysate

Anti-SOCS5 antibody - ab97283 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-SOCS5 antibody (ab97283) at 1/1000 dilution + Molt-4 whole cell lysate at 30 µg

Anti-SOCS5 antibody - ab56649 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
SOCS5 antibody (ab56649) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human smooth muscle.

Anti-SOCS5 antibody - ab88096 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-SOCS5 antibody (ab88096) at 1 µg/ml + U-2 OS cell lysate at 50 µg

Anti-SOCS5 antibody - ab13949 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SOCS5 antibody - N-terminal - ab166724 from Abcam

Host Rabbit
Clonality Polyclonal
All lanes : Anti-SOCS5 antibody - N-terminal (ab166724) at 1/1000 dilutionLane 1 : Mouse thymus total cell extractLane 2 : HeLa total cell extractLane 3 : Jurkat total cell extract

Anti-SOCS5 Antibody (C-Terminus) - LS-C33941 from LifeSpan Bioscience

Prices $285.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-SOCS5 Antibody (aa2-12) - LS-C55507 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-SOCS5 Antibody - LS-C809 from LifeSpan Bioscience

Prices $335.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis for SOCS5 using antibody at 1:500 dilution against 15 ug/lane of mouse spleen (lane A) and human spleen (lane B) lysates.

Anti-SOCS5 Antibody (clone 2D1) - LS-C133600 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2D1
Immunoperoxidase of monoclonal antibody to SOCS5 on formalin-fixed paraffin-embedded human small Intestine. [antibody concentration 3 ug/ml]

Anti-SOCS5 Antibody (aa1-42) - LS-C185649 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded Ca922 xenograft using SOCS5 antibody at 1:100 dilution.

SOCS-5 Antibody - NB100-56639 from Novus Biologicals

Prices $99.00, $229.00
Sizes 50 µl, 200 µl
Host Rabbit
Clonality Polyclonal
Western Blot: SOCS-5 Antibody [NB100-56639] - Analysis for SOCS5 using NB100-56639 at 1:500 dilution against 15 ug/lane of mouse spleen (lane A) and human spleen (lane B) lysates.

SOCS-5 Antibody - AF4796 from Novus Biologicals

Prices $99.00, $329.00
Sizes 25 µg, 100 µg
Host Goat
Clonality Polyclonal
Western blot shows lysates of HeLa human cervical epithelial carcinoma cell line. PVDF membrane was probed with 1 µg/mL of Goat Anti-Human SOCS‑5 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF4796) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF019). A specific band was detected for SOCS‑5 at approximately XXX kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 8.

SOCS-5 Antibody (516729) - MAB4796 from Novus Biologicals

Prices $99.00, $249.00
Sizes 25 µg, 100 µg
Host Mouse
Clonality Monoclonal
Clone 516729

SOCS-5 Antibody (2D1) - H00009655-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2D1
Western Blot: SOCS-5 Antibody (2D1) [H00009655-M01] - SOCS5 monoclonal antibody (M01), clone 2D1 Analysis of SOCS5 expression in HepG2.

SOCS-5 Antibody - NBP1-30990 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: SOCS-5 Antibody [NBP1-30990] - A. 50 ug mouse testis lysate/extract 7.5 % SDS-PAGE SOCS5 antibody dilution: 1:500

SOCS-5 Antibody - NBP1-85608 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: SOCS-5 Antibody [NBP1-85608] - Staining of human cell line U-2 OS shows localization to nucleoplasm & cytosol.

SOCS-5 Antibody - NB600-1166 from Novus Biologicals

Prices $369.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: SOCS5 Antibody [NB600-1166] - IHC: Localization of the antibody as the precipitated red signal, with a hematoxylin purple nuclear counterstain in cardiac myocytes within the heart.

SOCS-5 Antibody - H00009655-B01 from Novus Biologicals

Prices $349.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: SOCS5 Antibody [H00009655-B01] - analysis of SOCS5 expression in transfected 293T cell line by SOCS5 MaxPab polyclonal antibody (B01). Lane 1: SOCS5 transfected lysate (61.20 KDa). Lane 2: Non-transfected lysate.

SOCS-5 Antibody - H00009655-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: SOCS-5 Antibody [H00009655-B01P] - Analysis of SOCS5 expression in U-2 OS.
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