| Gene Symbol | SOCS5 |
|---|---|
| Entrez Gene | 9655 |
| Alt Symbol | CIS6, CISH6, Cish5, SOCS-5 |
| Species | Human |
| Gene Type | protein-coding |
| Description | suppressor of cytokine signaling 5 |
| Other Description | CIS-6|cytokine-inducible SH2 protein 6|cytokine-inducible SH2-containing protein 5 |
| Swissprots | O75159 Q8IYZ4 Q53SD4 |
| Accessions | AAY24289 EAX00235 EAX00236 EAX00237 O75159 AB014571 BAA31646 AF073958 AAD40484 AI433294 AK290194 BAF82883 AK296796 BAG59372 AL136896 CAB66830 BC032862 AAH32862 DQ891213 ABM82139 DQ894396 ABM85322 NM_014011 NP_054730 NM_144949 NP_659198 |
| Function | SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling. {ECO:0000269|PubMed:15590694}. |
| Top Pathways | Jak-STAT signaling pathway, Prolactin signaling pathway |
SOCS-5 CRISPR/Cas9 KO Plasmid (h) - sc-402585 from Santa Cruz Biotechnology
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SOCS-5 HDR Plasmid (h) - sc-402585-HDR from Santa Cruz Biotechnology
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SOCS-5 Double Nickase Plasmid (h) - sc-402585-NIC from Santa Cruz Biotechnology
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SOCS-5 Double Nickase Plasmid (h2) - sc-402585-NIC-2 from Santa Cruz Biotechnology
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SOCS-5 CRISPR Activation Plasmid (h) - sc-402585-ACT from Santa Cruz Biotechnology
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SOCS-5 CRISPR Activation Plasmid (h2) - sc-402585-ACT-2 from Santa Cruz Biotechnology
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SOCS-5 Lentiviral Activation Particles (h) - sc-402585-LAC from Santa Cruz Biotechnology
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SOCS-5 Lentiviral Activation Particles (h2) - sc-402585-LAC-2 from Santa Cruz Biotechnology
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SOCS-5 siRNA (h) - sc-41002 from Santa Cruz Biotechnology
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SOCS-5 shRNA Plasmid (h) - sc-41002-SH from Santa Cruz Biotechnology
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SOCS-5 shRNA (h) Lentiviral Particles - sc-41002-V from Santa Cruz Biotechnology
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SOCS-5 RNAi - H00009655-R02 from Novus Biologicals
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SOCS-5 RNAi - H00009655-R01 from Novus Biologicals
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MISSION® esiRNA - EHU109441 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN20324 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20324 from Sigma-Aldrich
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SOCS5 siRNA (Human) - CRH6432 from Cohesion Biosciences
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SOCS5 - MBS8213066 from MyBioSource
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SOCS-5 CRISPR/Cas9 KO Plasmid (h2) - sc-402585-KO-2 from Santa Cruz Biotechnology
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SOCS-5 HDR Plasmid (h2) - sc-402585-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human SOCS5 (NM_144949.2) - SHH414984 from Creative biogene
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shRNA set against Human SOCS5(NM_014011.4) - SHL024310 from Creative biogene
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shRNA set against Human SOCS5(NM_144949.2) - SHL024456 from Creative biogene
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Human SOCS5 siRNA - orb266934 from Biorbyt
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SOCS5 shRNA Plasmid (Human) - CHH6432 from Cohesion Biosciences
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