SOCS5

Gene Symbol	SOCS5
Entrez Gene	9655
Alt Symbol	CIS6, CISH6, Cish5, SOCS-5
Species	Human
Gene Type	protein-coding
Description	suppressor of cytokine signaling 5
Other Description	CIS-6|cytokine-inducible SH2 protein 6|cytokine-inducible SH2-containing protein 5
Swissprots	O75159 Q8IYZ4 Q53SD4
Accessions	AAY24289 EAX00235 EAX00236 EAX00237 O75159 AB014571 BAA31646 AF073958 AAD40484 AI433294 AK290194 BAF82883 AK296796 BAG59372 AL136896 CAB66830 BC032862 AAH32862 DQ891213 ABM82139 DQ894396 ABM85322 NM_014011 NP_054730 NM_144949 NP_659198
Function	SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling. {ECO:0000269|PubMed:15590694}.
Top Pathways	Jak-STAT signaling pathway, Prolactin signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SOCS5 full length protein - ab160596 from Abcam Category Protein Source Wheat germ Species Human

Human SOCS5 protein fragment - ab160597 from Abcam Category Protein Source Wheat germ Species Human

SOCS5 Antibody Blocking Peptide - LS-E25449 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human SOCS-5 Protein - H00009655-P02 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

Recombinant Human SOCS-5 Protein - H00009655-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

SOCS5-Antibody-N-term-Blocking-Peptide - BP19536a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SOCS5 blocking peptide - GTX89655-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Pig, Rat, Bovine

SOCS5 Peptide - AC21-0278-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

SOCS5 / CIS6 - H00009655-P02 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

SOCS5 / CIS6 - H00009655-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

SOCS5 / CIS6 - H00009655-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

SOCS5 Peptide - 46-411P from ProSci Category Peptide Species Human

SOCS5 fusion protein - ag3494 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human Suppressor of cytokine signaling 5(SOCS5) - CSB-YP022394HU CSB-EP022394HU CSB-BP022394HU CSB-MP022394HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

SOCS5 Protein - abx163446 from Abbexa Category Protein Species Human, Mouse, Rat

SOCS5 / CIS6 (N-term HIS tag, transcript variant 1) - TP760268 from Acris Antibodies Category Protein Prices $199.00 Sizes 50 µg Source E. coli Species Human

SOCS5, Peptide - MBS426817 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Pig, Bovine

SOCS-5 Recombinant Protein Antigen - NBP1-85608PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

SOCS5 Peptide, Human - M34GP14878H from Creative Peptides Category Peptide Source Synthetic. Species Human

Suppressor of cytokine signaling 5 (SOCS5), Recombinant Protein - MBS1019817 from MyBioSource Category Protein Prices $1,330.00, $1,330.00, $1,545.00, $1,545.00, $2,195.00, $2,195.00, $2,660.00, $2,660.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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