| Gene Symbol |
SOCS5
|
| Entrez Gene |
9655
|
| Alt Symbol |
CIS6, CISH6, Cish5, SOCS-5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
suppressor of cytokine signaling 5
|
| Other Description |
CIS-6|cytokine-inducible SH2 protein 6|cytokine-inducible SH2-containing protein 5
|
| Swissprots |
O75159 Q8IYZ4 Q53SD4
|
| Accessions |
AAY24289 EAX00235 EAX00236 EAX00237 O75159 AB014571 BAA31646 AF073958 AAD40484 AI433294 AK290194 BAF82883 AK296796 BAG59372 AL136896 CAB66830 BC032862 AAH32862 DQ891213 ABM82139 DQ894396 ABM85322 NM_014011 NP_054730 NM_144949 NP_659198
|
| Function |
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling. {ECO:0000269|PubMed:15590694}.
|
| Top Pathways |
Jak-STAT signaling pathway, Prolactin signaling pathway
|