SOCS5

Gene Symbol	SOCS5
Entrez Gene	9655
Alt Symbol	CIS6, CISH6, Cish5, SOCS-5
Species	Human
Gene Type	protein-coding
Description	suppressor of cytokine signaling 5
Other Description	CIS-6|cytokine-inducible SH2 protein 6|cytokine-inducible SH2-containing protein 5
Swissprots	O75159 Q8IYZ4 Q53SD4
Accessions	AAY24289 EAX00235 EAX00236 EAX00237 O75159 AB014571 BAA31646 AF073958 AAD40484 AI433294 AK290194 BAF82883 AK296796 BAG59372 AL136896 CAB66830 BC032862 AAH32862 DQ891213 ABM82139 DQ894396 ABM85322 NM_014011 NP_054730 NM_144949 NP_659198
Function	SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling. {ECO:0000269|PubMed:15590694}.
Top Pathways	Jak-STAT signaling pathway, Prolactin signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SOCS5-Over-expression-Lysate - LY15004a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

SOCS5 293T Cell Transient Overexpression Lysate(Denatured) - H00009655-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

SOCS5 overexpression lysate - LY402267 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

SOCS5 293 Cell Lysate - 401990 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

SOCS5 293 Cell Lysate - 404507 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

SOCS-5 Overexpression Lysate (Denatured) - H00009655-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

SOCS-5 Overexpression Lysate (Native) - NBL1-16329 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

SOCS-5 Overexpression Lysate (Native) - NBL1-16330 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

SOCS5 Over-expression Lysate Product - GWB-AD9F62 from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

SOCS5 Over-expression Lysate Product - GWB-6532C0 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

SOCS-5 Overexpression Lysate (Denatured) - H00009655-T02 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

Panoply™ Human SOCS5 Knockdown Stable Cell Line - CSC-DC014878 from Creative biogene Category Cell Line Species Human

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