SOCS5

Gene Symbol	SOCS5
Entrez Gene	9655
Alt Symbol	CIS6, CISH6, Cish5, SOCS-5
Species	Human
Gene Type	protein-coding
Description	suppressor of cytokine signaling 5
Other Description	CIS-6|cytokine-inducible SH2 protein 6|cytokine-inducible SH2-containing protein 5
Swissprots	O75159 Q8IYZ4 Q53SD4
Accessions	AAY24289 EAX00235 EAX00236 EAX00237 O75159 AB014571 BAA31646 AF073958 AAD40484 AI433294 AK290194 BAF82883 AK296796 BAG59372 AL136896 CAB66830 BC032862 AAH32862 DQ891213 ABM82139 DQ894396 ABM85322 NM_014011 NP_054730 NM_144949 NP_659198
Function	SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling. {ECO:0000269|PubMed:15590694}.
Top Pathways	Jak-STAT signaling pathway, Prolactin signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human-SOCS5-cDNA-Clone - DC06534 from Abgent, a WuXi AppTec company Prices $723.60 Sizes 10 µg Species Human Accession BC032862

SOCS5 - MBS1273618 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC032862

Human SOCS5 cDNA clone(NM_144949.2) - CDFG008754 from Creative Biomart Species Human Accession NM_144949.2

Human SOCS5 cDNA clone(NM_014011.4) - CDFH018309 from Creative Biomart Species Human Accession NM_014011.4

Human SOCS5 ORF clone(NM_014011.4) - CDCL186259 from Creative Biomart Species Human Accession NM_014011.4

human SOCS5 ORF clone - CDCH084388 from Creative Biomart Species Human Accession NM_014011

human SOCS5 ORF clone - CDCH084389 from Creative Biomart Species Human Accession NM_014011

Human SOCS5 ORF Clone(NM_014011.4) - CDCR296757 from Creative Biomart Species Human Accession NM_014011.4

Human SOCS5 ORF Clone(NM_014011.4) - CDCR296758 from Creative Biomart Species Human Accession NM_014011.4

Human SOCS5 ORF Clone(NM_014011.4) - CDCR296759 from Creative Biomart Species Human Accession NM_014011.4

Human SOCS5 ORF Clone(NM_144949.2) - CDCR317874 from Creative Biomart Species Human Accession NM_144949.2

Human SOCS5 ORF Clone(NM_144949.2) - CDCR317875 from Creative Biomart Species Human Accession NM_144949.2

Human SOCS5 ORF Clone(NM_144949.2) - CDCR317876 from Creative Biomart Species Human Accession NM_144949.2

Human SOCS5 Gene ORF cDNA clone in cloning vector - HG11317-M from Sino Biological Species Human

Human SOCS5 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG11317-ACG from Sino Biological Species Human

Human SOCS5 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG11317-NF from Sino Biological Species Human

Human SOCS5 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG11317-NM from Sino Biological Species Human

Human SOCS5 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG11317-CF from Sino Biological Species Human

Human SOCS5 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG11317-CM from Sino Biological Species Human

Human SOCS5 Gene ORF cDNA clone expression plasmid, N-HA tag - HG11317-NY from Sino Biological Species Human

Human SOCS5 Gene cDNA Clone (full-length ORF Clone), expression ready, untagged - HG11317-M-N from Sino Biological Species Human Accession NM_014011.4

Human SOCS5 Gene ORF cDNA clone expression plasmid, C-His tag - HG11317-CH from Sino Biological Species Human

Human SOCS5 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG11317-ANG from Sino Biological Species Human

Human SOCS5 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG11317-ACR from Sino Biological Species Human

Human SOCS5 Gene ORF cDNA clone expression plasmid - HG11317-UT from Sino Biological Species Human

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